I-10-DAB Semi-Synthetic Paclitaxel: Ingqophamlando Emkhakheni Wokuhlanganiswa Kwezidakamizwa

I-Paclitaxel iwumuthi obalulekile osetshenziswa kabanzi ekwelapheni umdlavuza, kodwa imithombo yawo yemvelo inomkhawulo.Ukuze kuhlangatshezwane nesidingo se-paclitaxel emakethe yezemithi, ososayensi benze ucwaningo olubanzi, ngezindlela ze-semi-synthetic eziba indlela ebalulekile yokukhiqiza.Lesi sihloko sizokwethula inqubo ye-semi-synthesizing paclitaxel kusuka ku-10-deacetylbaccatin III (10-DAB) futhi sigcizelele ukubaluleka kwayo emkhakheni wokuhlanganiswa kwezidakamizwa.

I-Paclitaxel, ekuqaleni eyayiqhelelene namagxolo esihlahla se-yew sasePacific, yaziwa ngezakhiwo zayo ezivelele zokulwa nomdlavuza.Kodwa-ke, i-Pacific yew iyinsiza yemvelo enomkhawulo, eyanele ukuhlangabezana nesidingo sesimanje sezokwelapha se-paclitaxel.Ukuthuthukiswa kwezindlela ze-semi-synthetic kwenze ukukhiqizwa kwe-paclitaxel ngezinga elikhulu kwaba nokwenzeka, kanti i-10-deacetylbaccatin III ibe yinto ephakathi nendawo ebalulekile.

Ukulungiswa kwe-10-DAB ku-Semi-Synthetic Paclitaxel:

I-10-DAB iyindlela emaphakathi ebalulekile kumzila we-semi-synthetic eya ku-paclitaxel futhi idinga izinyathelo ezimbalwa zokuyilungiselela.Ngokuvamile, ukuhlanganiswa kwe-10-DAB kuqala nge-precursor yemvelo ye-paclitaxel, taxuyunnanine C, etholakala ku-baccatin III.I-Baccatin III ekuqaleni i-deacetylated ukuze ikhiqize i-10-deacetylbaccatin III.Kamuva, i-10-deacetylbaccatin III ibhekana nokusabela okuningi, okuhlanganisa i-hydrogenation, i-substitution, i-epoxidation, i-hydrolysis, nokunye, ekugcineni iguqule ibe yi-10-DAB.

Izinhlelo zokusebenza ze-10-DAB ku-Semi-Synthetic Paclitaxel:

Ukuhlanganiswa kwe-10-DAB kuvule indlela entsha ye-semi-synthesis ye-paclitaxel, ehlinzeka ngokusimama ekukhiqizweni kwezidakamizwa.I-Paclitaxel iyisidakamizwa esilwa nomdlavuza esibanzi esisetshenziswa ekwelapheni izinhlobo ezahlukene zomdlavuza, okuhlanganisa umdlavuza wesibeletho, webele, nowamaphaphu.Indlela ye-semi-synthetic inciphisa izindleko zokukhiqizwa kwezidakamizwa, okwenza le nketho yokwelashwa ebalulekile ifinyeleleke kalula ezigulini.

Isiphetho:

Indlela ye-semi-synthesizing paclitaxel esuka ku-10-DAB izuze impumelelo ebalulekile emkhakheni wokuhlanganiswa kwezidakamizwa.Ayigcini nje ngokubhekana nendaba yemithombo yemvelo elinganiselwe ye-paclitaxel kodwa futhi ithuthukisa ukusebenza kahle kokukhiqiza nokuzinza.Lobu buchwepheshe bumele ingqopha-mlando ekukhiqizweni kwemithi elwa nomdlavuza futhi bunesithembiso sentuthuko eyengeziwe emkhakheni wezokwelapha ukuze kuliwe nezifo ezimbi kakhulu njengomdlavuza.Esikhathini esizayo, abacwaningi bazoqhubeka nokuhlanza izindlela zokuhlanganisa ukuze kuthuthukiswe ukusebenza kahle nokunciphisa izindleko, ekugcineni bazuze uhla olubanzi lweziguli.

Qaphela: Izinzuzo ezingaba khona kanye nezicelo ezishiwo kulesi sihloko zisekelwe ezincwadini ezitholakala esidlangalaleni.

Ukufunda Okungeziwe: I-Yunnan Hande Biotech Co., Ltd., eneminyaka engu-26 igxile ekukhiqizeni i-paclitaxel, ingumkhiqizi ozimele ogunyazwe umhlaba wonke wezithako ezisebenzayo zemithi ye-anticancer ekhishwe esitshalweni, egunyazwe izinhlangano ezilawulayo ezifana ne-US FDA, European EDQM. , Australia TGA, China CFDA, India, Japan, nabanye.I-Yunnan Hande Paclitaxel, etholakala esitokweni, ithengiswa ngokuqondile ngumkhiqizi.Sicela uzizwe ukhululekile ukushayela imibuzo ku- +86 18187887160 (WhatsApp).