Isakhiwo samakhemikhali kanye nesenzo se-pharmacological se-paclitaxel

I-Paclitaxel (i-Paclitaxel) iyisidakamizwa semvelo esilwa nomdlavuza esikhishwe esitshalweni se-yew, esinokwakheka kwamakhemikhali okuyingqayizivele kanye nemiphumela yemithi.Selokhu kwatholakala i-paclitaxel ngo-1971, ukusetshenziswa kwayo emtholampilo kuzuze imiphumela emangalisayo.Kuleli phepha, isakhiwo samakhemikhali kanye nesenzo se-pharmacological ofpaclitaxelkuzoxoxwa ngakho.

Isakhiwo samakhemikhali se-paclitaxel

Isakhiwo samakhemikhali se-paclitaxel siyinkimbinkimbi, sihlanganisa izakhiwo eziningana zendandatho, kuhlanganise nesakhiwo se-diterpenoid esiyinhloko, okuyingxenye ebalulekile yomphumela wokulwa nomdlavuza we-paclitaxel.Ama-molecule e-Paclitaxel aqukethe nenani lamaqembu e-hydroxyl ne-ketone, futhi indawo nenombolo yala maqembu inquma umsebenzi wayo oyingqayizivele wezokwelapha.

Imiphumela ye-pharmacological ye-paclitaxel

1. Ukuqiniswa kwe-Microtubule: I-Paclitaxel ingakhuthaza i-polymerization yama-microtubules futhi iqinise ama-microtubules e-polymerized, okuyindlela eyinhloko yomphumela wayo wokulwa nomdlavuza.Ama-Microtubules adlala indima ebalulekile ekuhlukaneni kwamaseli, futhi i-paclitaxel ivimbela ukukhula kwesimila ngokusimamisa ama-microtubules nokuvimbela ukuhlukana kwamaseli.

2, bangela ukuboshwa komjikelezo weseli: i-paclitaxel ingaphinda ibangele ukuboshwa komjikelezo weseli, ukuze amaseli angakwazi ukuqhubeka nokuhlukana nokwanda.Lena enye indlela ebalulekile yomphumela wayo wokulwa nomdlavuza.

3, bangela i-apoptosis: i-paclitaxel ingaheha ukuvezwa kwabalamuli abambalwa be-pro-apoptosis, isheshise inqubo ye-apoptosis yamaseli omdlavuza.

I-4, ukulawulwa kwabaxhumanisi be-anti-apoptotic: i-paclitaxel ingaphinde ilawule umsebenzi wabaxhumanisi be-anti-apoptotic ukulinganisa inqubo ye-apoptosis nokwanda.

Isiphetho

I-Paclitaxel iwuhlobo lomuthi wemvelo wokulwa nomdlavuza onesakhiwo samakhemikhali esiyingqayizivele kanye nesenzo sekhemisi.Inganqanda ngempumelelo ukukhula kwesimila ngokukhuthaza ukwenziwa kwe-microtubule polymerization, ukusimamisa ama-microtubules enziwe nge-polymerized, kubangele ukuboshwa komjikelezo wamaseli kanye nokwenza i-cell apoptosis.Kodwa-ke, ubuthi nemiphumela engemihle ye-paclitaxel nakho kuyakhathaza ekusetshenzisweni komtholampilo.Ucwaningo olwengeziwe nokuqonda imiphumela ye-pharmacological ye-paclitaxel kuzosiza ukwandisa ukusetshenziswa kwayo emtholampilo, kuthuthukise ukusebenza kahle kokwelapha, nokunciphisa imiphumela emibi.

Ikusasa Outlook

Nakuba ukusetshenziswa komtholampilo kwe-paclitaxel kuzuze imiphumela emangalisayo, inkinga yezinsiza zayo ezilinganiselwe kanye nokunikezwa okuqinile kusekhona.Ngakho-ke, ososayensi emkhakheni webhayoloji yokwenziwa kanye namakhemikhali emithi basebenzela ukuthola ezinye izindlela esikhundleni se-paclitaxel ukuze baxazulule izinkinga zayo zokuhlinzeka nokunciphisa izindleko zokukhiqiza.Ngaphezu kwalokho, ucwaningo ngemiphumela ye-pharmacological yepaclitaxelkuzosiza futhi ukuthola amasu okwelapha asebenza kangcono ukulwa nezinhlobo ezahlukene zomdlavuza.

Ocwaningweni lwangaphambi komtholampilo nasezivivinyweni zomtholampilo, inhlanganisela ye-paclitaxel neminye imithi elwa nomdlavuza ibonise amathuba athembisayo.Ngokuhlanganisa i-paclitaxel nezinye izidakamizwa, ukuphumelela kokwelashwa kungathuthukiswa futhi ukuvela kokungazweli kuncishiswe.Ngokuzayo, ngokusakazwa komuthi onembayo nemiqondo yokwelapha yomuntu siqu, ucwaningo nokuqonda imiphumela ye-pharmacological ye-paclitaxel izojula kakhulu, futhi nezinhlelo zokwelapha ezinembe kakhudlwana zizonikezwa iziguli ezinomdlavuza.

Ngokuvamile, i-paclitaxel iyisidakamizwa semvelo esilwa nomdlavuza esinesakhiwo samakhemikhali esiyingqayizivele kanye nemiphumela yemithi.Ngokuqhubeka okuqhubekayo kwesayensi nobuchwepheshe kanye nocwaningo olujulile, sibheke ngabomvupaclitaxelukudlala indima enkulu ekwelapheni imidlavuza ehlukahlukene esikhathini esizayo, okuletha imiphumela yokwelashwa engcono kanye nezinga lempilo ezigulini.

Qaphela: Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.