I-Paclitaxel, umuthi wemvelo wokulwa nomdlavuza onefomula ethi C47H51NO14, isetshenziswe kabanzi ekwelapheni umdlavuza webele, umdlavuza wesibeletho kanye nomdlavuza wekhanda, intamo namaphaphu.Njenge-alkaloid ye-diterpenoid enomsebenzi wokulwa nomdlavuza,paclitaxeliye yathakazelelwa kakhulu izazi zezitshalo, osokhemisi, osokhemisi kanye nezazi zebhayoloji yamangqamuzana ngenxa yenoveli yayo kanye nesakhiwo samakhemikhali esiyinkimbinkimbi, umsebenzi omkhulu nobalulekile wezinto eziphilayo, indlela entsha neyingqayizivele yokusebenza, kanye nemithombo yemvelo eyivelakancane, okuyenza ibe inkanyezi nokugxila ocwaningweni lwe-anticancer ingxenye yesibili yekhulu lama-20.
Indlela yokusebenza ye-paclitaxel
I-Paclitaxel ivimbela ukwanda kwamangqamuzana omdlavuza ikakhulukazi ngokufaka ukuboshwa komjikelezo wamaseli nokudangala inhlekelele ye-mitotic.Inoveli yayo kanye nesakhiwo samakhemikhali esiyinkimbinkimbi siyinikeza indlela yokusebenza eyingqayizivele yezinto eziphilayo.I-Paclitaxelingavimbela ukwanda kwamaseli ngokuvimbela i-polymerization ye-tubulin futhi ibhubhise inethiwekhi ye-cell microtubule.Ngaphezu kwalokho, i-paclitaxel ingaphinda ihehe ukuvezwa kwabaxhumanisi be-pro-apoptotic futhi ilawule umsebenzi wabalamuli be-anti-apoptotic, ngaleyo ndlela idale i-apoptosis yamaseli omdlavuza.
Umsebenzi wokulwa nomdlavuza we-paclitaxel
I-Paclitaxel idonse ukunaka okukhulu ngenxa yokusebenza kahle kwayo okuphezulu kanye nobuthi obuphansi bomsebenzi wokulwa nomdlavuza.Emisebenzini yomtholampilo, i-paclitaxel iboniswe ukuthi inemiphumela ebalulekile yokwelapha ezinhlobonhlobo zomdlavuza, okuhlanganisa umdlavuza webele, umdlavuza wesibeletho, umdlavuza wekhanda nentamo, kanye nomdlavuza wamaphaphu.Ngomshini wayo oyingqayizivele webhayoloji, i-paclitaxel inganqanda ngempumelelo ukwanda kwamaseli omdlavuza futhi yenze i-apoptosis yamaseli omdlavuza.Ngaphezu kwalokho, umsebenzi wokulwa nomdlavuza we-paclitaxel nawo uhlobene nekhono layo lokulawula ukuphendula kwamasosha omzimba kumaseli wesimila.
Ukushoda kwensiza ye-paclitaxel
Nakuba i-paclitaxel inomsebenzi obalulekile wokulwa nomdlavuza, ukushoda kwensiza yayo kukhawulele ukusetshenziswa kwayo komtholampilo okusabalele.I-Paclitaxel ikhishwa kakhulu ezihlahleni ze-yew zasePacific, futhi ngenxa yezinsiza zemvelo ezilinganiselwe, ukukhiqizwa kwe-paclitaxel kusekude ukuhlangabezana nezidingo zomtholampilo.Ngakho-ke, ukusesha kwemithombo emisha ye-paclitaxel, njengokukhiqizwa kwe-paclitaxel nge-biosynthesis noma i-chemical synthesis, kugxile ocwaningweni lwamanje.
isiphetho
Njengomuthi wemvelo wokulwa nomdlavuza,paclitaxelinezici zokusebenza kahle kakhulu, ubuthi obuphansi kanye ne-spectrum ebanzi, futhi indlela yayo eyingqayizivele yezinto eziphilayo kanye nomsebenzi obalulekile wokulwa nomdlavuza kuwenza umuthi obalulekile wokwelapha umdlavuza ekusebenzeni komtholampilo.Kodwa-ke, ngenxa yokushoda kwezinsiza zayo, ukusetshenziswa kwayo okubanzi emisebenzini yomtholampilo kunqunyelwe.Ngakho-ke, ucwaningo lwesikhathi esizayo kufanele lugxile ekutholeni imithombo emisha ye-paclitaxel ukuze ihlangabezane nezidingo zomtholampilo futhi inikeze izinketho zokwelashwa ezengeziwe zeziguli ezinomdlavuza.
Qaphela: Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.
Isikhathi sokuthumela: Nov-24-2023