Inqubo Yokukhiqiza Nobuchwepheshe be-Paclitaxel API

I-Paclitaxel iyisidakamizwa esenzeka ngokwemvelo esinomsebenzi obalulekile wokulwa nomdlavuza, osetshenziswa kabanzi ekwelapheni imidlavuza ehlukahlukene. Ngokukhula kwesidingo somtholampilo, inqubo yokukhiqiza kanye nobuchwephesheI-Paclitaxel APInazo ziyathuthuka ngokuqhubekayo.Le ndatshana izokwethula inqubo yokukhiqiza nobuchwepheshe be-Paclitaxel API ngokuningiliziwe.

I.Umthombo kanye Nokukhishwa kwe-Paclitaxel

I-Paclitaxel isuselwa kakhulu ku-Taxus brevifolia,Taxus cuspidata,Taxus wallichiana nezinye izinhlobo ze-Taxus.Izindlela zokukhipha ikakhulukazi zihlanganisa i-solvent extraction,i-ultrasonic extraction,i-microwave extraction,etc.I-Solvent extraction iyindlela evame ukusetshenziswa,kodwa inezinkinga ezifana nesikhathi eside sokukhipha kanye nokusetshenziswa okukhulu kwezinyibilikisi.Ngakho-ke, eminyakeni yamuva nje, abacwaningi bebelokhu bezama izindlela ezintsha zokukhipha, njenge-enzyme hydrolysis, ukukhishwa koketshezi oluphakeme kakhulu, njll., ukuthuthukisa ukusebenza kahle nokuhlanzeka kokukhipha.

II.Inqubo Yokukhiqiza ye-Paclitaxel

Indlela yokuvutshelwa yokukhiqiza i-Paclitaxel

Eminyakeni yamuva nje, izindlela zokuvutshelwa ziye zacwaningwa kakhulu ekukhiqizeni i-Paclitaxel.Le ndlela isebenzisa ubuchwepheshe bokuvutshelwa kwe-microbial ukukhiqiza i-Paclitaxel ngokuhlakulela nokuvundisa amaseli e-Taxus.Le ndlela inezinzuzo ezinjengomjikelezo omfushane wokukhiqiza, isivuno esiphezulu, nokuhlanzeka okuphezulu. , idinga ukuthuthukiswa kwezimo zokuvutshelwa kanye nokuhlolwa kwezinhlobo ezikhiqiza kakhulu ukuze kuthuthukiswe ukusebenza kahle kokukhiqiza nokunciphisa izindleko.

Indlela ye-Chemical synthesis yokukhiqiza i-Paclitaxel

I-Chemical synthesis ingenye indlela ebalulekile yokukhiqiza i-Paclitaxel.Le ndlela isebenzisa ubuchwepheshe be-organic synthesis ukuze ihlanganise i-Paclitaxel ngokusebenzisa imizila yokuhlanganisa amakhemikhali.Nakuba le ndlela inezinzuzo ezifana nokukhiqizwa okukhulu nokuhlanzeka okuphezulu, inezinkinga ezifana nemizila emide yokwenziwa kanye izindleko eziphezulu, ezinciphisa ukusetshenziswa kwayo okungokoqobo.

Inhlanganisela yokukhishwa kwemvelo kanye nokuhlanganiswa kwamakhemikhali ohlelweni lokukhiqiza

Ukuze unqobe ukulinganiselwa kwezindlela zokukhiqiza ezilodwa, abacwaningi bahlola futhi inhlanganisela yokukhishwa kwemvelo kanye nokuhlanganiswa kwamakhemikhali enqubweni yokukhiqiza.Le ndlela iqala ngokukhipha izinto ezandulela i-Paclitaxel ezinhlotsheni ze-Taxus zisebenzisa i-solvent extraction, bese iziguqulela ku-Paclitaxel isebenzisa ukuhlanganiswa kwamakhemikhali. ubuchwepheshe.Le ndlela ihlanganisa izinzuzo zokukhishwa kwemvelo kanye nokuhlanganiswa kwamakhemikhali, ithuthukisa ukusebenza kahle kokukhiqiza nobumsulwa, futhi yehlisa izindleko zokukhiqiza.

III.Izinselele kanye Neziqondiso Zokuthuthukisa ku-Paclitaxel Production Technology

Ukuthuthukisa ukusebenza kahle nokuhlanzeka kokukhipha: Ukuthuthukisa izindlela zokukhipha ezisebenza kahle nezivumelana nemvelo kanye nobuchwepheshe, njengezincibilikisi ezintsha, ama-enzyme ahlanganisiwe, njll., ukuthuthukisa ukusebenza kahle nokuhlanzeka kwe-Paclitaxel.

Ukuthuthukisa izimo zokuvutshelwa kanye nokuhlola izinhlobo ezithela kakhulu: Ukuthuthukisa izimo zokuvubela (ezifana nokwakheka okuphakathi, izinga lokushisa, inani le-pH, njll.) nokuhlola izinhlobo ezithela kakhulu ukuze kwandiswe isivuno nobumsulwa bokukhiqizwa kwe-Paclitaxel okusekelwe ekuvubeleni.

Ukunciphisa izindleko zokukhiqiza: Ukuthuthukisa izinto ezintsha zokusetshenziswa, ukuthuthukisa izinqubo zokukhiqiza, nokuzuza ukukhiqizwa kwenani elikhulu ukuze kwehliswe izindleko zokukhiqiza ze-Paclitaxel futhi kuthuthukiswe ukuncintisana kwayo ezimakethe.

Ukuqinisa ukulawulwa kwekhwalithi: Ukusungula uhlelo oluphelele lokulawula ikhwalithi ukuze ulawule ngokuqinile ikhwalithi yezinto ezingavuthiwe, izinqubo zokukhiqiza, nemikhiqizo ngokulawulwa kwekhwalithi okuqinile nokuhlolwa kokuhlaziya ukuze kuqinisekiswe ikhwalithi nokuphepha komkhiqizo.

Ukuthuthukisa amafomula amasha: Ukuthuthukisa amafomula amasha (njengama-nanomaterials, amafomu e-liposome, njll.) ukuze kuthuthukiswe ukutholakala kwe-bioavailability nokusebenza ngempumelelo kwe-Paclitaxel ku-vivo ngokusekelwe ekushiyekeni kwayo ekusetshenzisweni komtholampilo.

Ukwandisa izinkambu zohlelo lokusebenza:Ukunweba ngokuqhubekayo izinkambu zokusetshenziswa kwe-Paclitaxel ngaphezu kokwelashwa komdlavuza (okufana nemiphumela eqeda ukuvuvukala, i-antioxidant), ukuze kusetshenziswe imiphumela yayo ebanzi yezemithi kanye nenani lokusetshenziswa.

IV.Isiphetho kanye Namathemba

Ngokuthuthuka okuqhubekayo kwesayensi nobuchwepheshe kanye nesidingo esikhulayo somtholampiloI-Paclitaxel API,inqubo yokukhiqiza kanye nobuchwepheshe be-Paclitaxel API nakho kuthuthuka ngokuqhubekayo.Esikhathini esizayo, abacwaningi bazoqhubeka nokuhlola izinqubo ezintsha zokukhiqiza kanye nezindlela zobuchwepheshe zokuthuthukisa ukusebenza kahle kokukhiqiza kwe-Paclitaxel, ukunciphisa izindleko zokukhiqiza, ukunweba izinkundla zokufaka isicelo, futhi benze iminikelo emikhulu. empilweni yomuntu.

Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezishiwo kulesi sihloko kuthathwe ezincwadini ezishicilelwe esidlangalaleni.