I-Paclitaxel iyisidakamizwa esisetshenziswa kakhulu sokwelapha umdlavuza, esasuka ku-Pacific yew tree(Taxus brevifolia) .Nokho, indlela yokukhipha kulesi sihlahla iye yaholela emthelela wemvelo ongalawuleki, okwenza ososayensi bafune imithombo eqhubekayo ukuze bahlangabezane nezidingo zezokwelapha. Lesi sihloko sihlola umsuka we-paclitaxel, ezinye izindlela, nentuthuko yesikhathi esizayo.
I-Paclitaxeliyisidakamizwa esiphumelelayo sokulwa nomdlavuza esisetshenziselwa ukwelapha izinhlobo ezihlukahlukene zomdlavuza, okuhlanganisa umdlavuza wesibeletho, umdlavuza webele, nomdlavuza wamaphaphu wamangqamuzana ongewona omncane. Noma kunjalo, indlela yangaphambili yokukhipha yayincike ngokuyinhloko ekuvuneni amagxolo namaqabunga esihlahla se-yew sasePacific, okuholela ekutheni ukuncipha okukhulu kwenani lalezi zihlahla.Lokhu kwaphakamisa ukukhathazeka kwemvelo, njengoba lezi zihlahla zikhula kancane futhi azikufanelanga ukuvunwa okukhulu.
Ukuze kuxazululwe le nkinga, ososayensi bebematasa befuna eminye imithombo nezindlela zokuthola i-paclitaxel. Nazi ezinye izindlela ezisacwaningwayo njengamanje:
1.Taxus yunnanensis:Lesi sihlahla se-yew, esidabuka e-China, siphinde sibe ne-paclitaxel.Abacwaningi bebelokhu behlola ukuthi kungenzeka yini ukukhipha i-paclitaxel ku-Taxus yunnanensis, engasiza ekunciphiseni ukuncika esihlahleni se-Pacific yew.
2.I-Chemical Synthesis:Ososayensi bebephenya izindlela zokwenza i-paclitaxel amakhemikhali. Nakuba lena kuyindlela esebenzayo, ngokuvamile ihilela izinyathelo eziyinkimbinkimbi ze-organic synthesis futhi kuyabiza.
3.Ukuvutshelwa: Ukusebenzisa ukuvutshelwa kwe-microbial ukukhiqiza i-paclitaxel enye indawo yocwaningo.Le ndlela inesithembiso sokunciphisa ukuthembela ekukhishweni kwezitshalo.
4.Ezinye Izitshalo:Ngaphezu kwe-Pacific yew ne-Taxus yunnanensis, ezinye izitshalo ziyacwaningwa ukuze kutholwe ukuthi i-paclitaxel ingakhishwa yini kuzo.
Nakuba ukufuna imithombo esimeme kakhudlwana ye-paclitaxel kuqhubeka, kubaluleke kakhulu. indlela yokukhiqiza kufanele iqinisekiswe ngokuqinile ngokwesayensi kanye nokubuyekezwa kokulawula ukuze kuqinisekiswe ikhwalithi nokuphepha komuthi.
Sengiphetha, ukufuna imithombo esimeme kakhudlwanapaclitaxeliyindawo yocwaningo ebalulekile enekhono lokuqhuba intuthuko esimeme ekwelapheni umdlavuza kuyilapho kulondolozwa indawo yemvelo.Ucwaningo lwesayensi lwesikhathi esizayo kanye nezinqubo ezintsha zobuchwepheshe zizoqhubeka nokusinikeza ezinye izindlela ezihlukile zokuhlangabezana nezidingo zezokwelapha.
Isikhathi sokuthumela: Oct-23-2023