I-Paclitaxel, isakhi semvelo esinamandla okulwa nomdlavuza, isibe yingxenye ebalulekile yokwelashwa komdlavuza.Into ebizwa ngokuthi i-taxol, isuselwa egxolweni lesihlahla se-yew futhi iyi-alkaloid ye-diterpenoid.Emashumini ambalwa eminyaka adlule,paclitaxelikhombise ukusebenza ngempumelelo okukhulu ekwelapheni izinhlobo ezahlukene zomdlavuza, okuhlanganisa owebele, owesibeletho, nomdlavuza wekhanda nentamo namaphaphu.
Okokuqala, umsebenzi wokulwa nomdlavuza we-paclitaxel uyisisekelo se-pharmacological properties.Ingakwazi ukulawula ngempumelelo ukukhula kwamangqamuzana e-tumor futhi ivimbele ukusabalala kanye nama-metastasis wamathumba ngokuvimbela inqubo ye-unhelix ye-DNA futhi ngaleyo ndlela ivimbele ukuphindaphinda kwe-DNA. itholakala ikakhulukazi ngokuzinzisa i-tubulin, ukuvimbela i-mitosis kanye nokwenza i-apoptosis.
Emisebenzini yomtholampilo, i-paclitaxel isetshenziswe kabanzi ekwelapheni umdlavuza webele. Ngokuhlanganisa, i-paclitaxel ingathuthukisa kakhulu ukusinda kwesiguli, yehlise ukubuya kwesimila, futhi ithuthukise izinga lempilo yeziguli. Ngokuvimbela ukuphindaphindeka kwe-DNA yamaseli wesimila kanye nokwenza i-apoptosis, i-paclitaxel ingalawula ngempumelelo ukukhula kwesimila futhi andise ukuphila kweziguli.
Ngaphezu komdlavuza webele kanye nesibeletho,paclitaxeliphinde yabonisa imiphumela emihle ekwelapheni eminye imidlavuza yekhanda nentamo kanye nomdlavuza wamaphaphu.Kulezi zindlela zokwelapha isimila, i-paclitaxel ivamise ukusetshenziswa ngokuhlangana neminye imithi elwa nomdlavuza ukuze kuzuzwe umphumela wokwelapha ophumelelayo.
Nokho, nakuba umphumela wokwelapha we-paclitaxel ubalulekile, kungase kube khona ukusabela okungekuhle ngesikhathi sokusetshenziswa.Iziguli zingase zibe nezimpawu ezifana nokucindezelwa komnkantsha, ukukhubazeka kwesibindi nezinso, ukusabela kwamathumbu emathunjini, ukungezwani komzimba nezinto ezithile, noma i-vasculitis ngemva kokusetshenziswa kwe-paclitaxel.Ngakho-ke, lapho usebenzisa i-paclitaxel, kuyadingeka ukubhekisisa isimo sokusabela kweziguli, kanye nokungenelela komtholampilo okufika ngesikhathi ukuze kuncishiswe ukusabela okubi.
Ngenjwayelo,paclitaxelibambe iqhaza elibalulekile ekwelapheni umdlavuza futhi inamandla amakhulu ezinhlobonhlobo zezimila eziyingozi.Nakuba kukhona ukusabela okungekuhle, ngokusebenzisa isiqondiso semithi enengqondo kanye nokuqapha komtholampilo, inganciphisa ngempumelelo ingozi engase ibe khona futhi yandise umphumela wayo wokwelapha.Ngokuqhubekayo. inqubekelaphambili yesayensi nobuchwepheshe kanye nokuqonda okujulile kwemiphumela yemithi ye-paclitaxel ngabacwaningi, sinesizathu sokukholelwa ukuthi kuzoba nemishanguzo ye-paclitaxel emisha futhi esebenza kangcono esikhathini esizayo, okuletha izinketho eziningi zokwelapha nethemba ezigulini ezinomdlavuza.
Qaphela:Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.
Isikhathi sokuthumela: Nov-14-2023