I-Unique Anti-Tumor Mechanism ye-Paclitaxel

I-Paclitaxel iyisidakamizwa esihle kakhulu semvelo sokulwa nomdlavuza esitholwe njengamanje.Isetshenziswa kabanzi ekwelapheni umdlavuza we-ovarian, umdlavuza webele, umdlavuza wamaphaphu, izimila zekhanda nentamo, umdlavuza womminzo, umdlavuza wesisu kanye ne-soft tissue sarcoma.I-Paclitaxelidonse isasasa elikhulu kososayensi ngenxa yesakhiwo sayo samakhemikhali esiyinkimbinkimbi nenoveli, izindlela zokwenza izinto eziphilayo eziyingqayizivele, umsebenzi onokwethenjelwa wokulwa nomdlavuza, nokushoda okukhulu kwezinsizakusebenza. Ngokwezibalo, ngaphezu kwama-laboratories aphezulu angama-30 emhlabeni wonke abambe iqhaza ocwaningweni lwe-Total. ukuhlanganiswa kwe-paclitaxel, futhi umncintiswano unolaka kakhulu, osekugxilwe kuwo amakhemikhali okwenziwa kwezinto eziphilayo ngasekupheleni kwekhulu lama-20.

Indlela ehlukile yokulwa nesimila ye-paclitaxel

I-Paclitaxel ingenza i-Tubulin ne-Tubulin dimer eyenza ama-microtubules alahlekelwe yi-Dynamic equilibrium, ikhuthaze futhi ikhuthaze i-Tubulin polymerization, ukuhlanganiswa kwe-microtubule, futhi ivimbele i-depolymerization, ukuze kuqiniswe ama-microtubules futhi kuvimbele i-Mitosis yamangqamuzana omdlavuza futhi kubangele i-apoptosis, ngaleyo ndlela kuvimbele ngempumelelo ukwanda komdlavuza. amaseli nokudlala indima yokulwa nomdlavuza.

Eqinisweni, i-Tubulin, ehlobene kakhulu ne-cell Mitosis, ikhona cishe yonke indawo kuwo wonke amangqamuzana e-eukaryotic. ukuhlakazeka kwesando njengama-microtubules kungabulala ngokukhethekile amaseli ngokuhlukana okungavamile.Eminye imithi ebalulekile yokulwa nomdlavuza, njenge-colchicine, i-Vinblastine, i-Vincristine, idlala indima yokulwa nesimila ngokuvimbela i-Tubulin ekubeni i-polymerization.

Ngokuphambene nezidakamizwa ze-anti-Mitosis kanye ne-anti-tumor,paclitaxelumuthi wokuqala otholakele ongasebenzisana ne-Tubulin polymer, okungukuthi, usebenza ngokuhlanganisa eduze nama-microtubules ukuze azinze.Ngaso leso sikhathi, kutholakala ukuthi i-paclitaxel ibonisa imiphumela emihle kumaseli ahlukahlukene aqinile. ukutholakala kuye kwaheha izazi zebhayoloji eziningi ukuba zisebenzisepaclitaxelnjengethuluzi locwaningo ku-biomedicine, ukuhlola izinkambu ezingaziwa zomsebenzi wamaseli nokuthola izindlela ezintsha zemithi elwa nomdlavuza.

Incazelo: Ukusebenza okunamandla kanye nezinhlelo zokusebenza ezishiwo kulesi sihloko konke kuvela ezincwadini ezitholakala esidlangalaleni.

I-Yunnan Hande Bio-tech ibigxile ekukhiqizweni kwe-paclitaxel iminyaka engama-28.Kuyibhizinisi elizimele lokukhiqiza lezinto zokusetshenziswa ze-paclitaxel, ezigunyazwe ama-ejensi alawulayo kazwelonke afana ne-FDA e-United States, i-EDQM eYurophu, i-TGA e-Australia, i-CFDA e-China, e-India nase-Japan.Yunnan Handepaclitaxelitholakala esitokweni futhi idayiswa abakhiqizi ngokuqondile.Siyakwamukela ukubuza.