Izinzuzo ze-Albumin-bound paclitaxel

I-Paclitaxel ingenye yezinhlobo ezintathu zemithi yokwelapha ngamakhemikhali, kodwa ukuncibilika kwayo emanzini akukubi futhi idinga ukuncibilika ngezincibilikisi eziphilayo.I-Albumin-bound bound paclitaxel isebenzisa i-nanotechnology ukukhulisa ukulethwa kwezidakamizwa kanye nokutholakala kwe-paclitaxel nge-bioavailability ngosizo lwe-albumin yemvelo. igwema kuphela ukungezwani komzimba/ubuthi obubangelwa izinyibilikisi eziphilayo, kodwa futhi ayidingi ukwelashwa kusengaphambili kwe-hormone; Ingenza futhi i-albumin ithwale i-paclitaxel iphume egazini ngokushesha okukhulu, idlule kumaseli e-endothelial ngokusebenzisa i-receptor mediated endocytosis, futhi inothise okwengeziwe ezicutshini zesimila. ngomphumela ophezulu wokungena kanye nokugcinwa (umphumela we-EPR) wamathumba, oqhubeka nokubonisa izinzuzo ze-pharmacokinetic.

Esikhathini se-immunotherapy, ukusebenza kahle komuthi owodwa akwanele, futhi izinga lokukhululwa kwenhloso (ORR) lomuthi owodwa alidluli ama-20%; indlela yokwelapha ngamakhemikhali ehlanganisiwe iyindawo eshisayo yokuhlola kwamanje.

Kulo mbono, i-Albumin-bound bound paclitaxel inezayo izinzuzo, i-ORR yayo iphakeme, ingabulala amangqamuzana e-tumor ngempumelelo, futhi ikhuthaze ukuvezwa kwe-tumor antigen; Akukho ukwelashwa kwe-hormone okudingekayo ukuze kugwenywe ukuvinjelwa kokuzivikela komzimba; izicubu ezijwayelekile.

Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezethulwe kulesi sihloko konke kuvela ezincwadini ezishicilelwe.

I-Yunnan Hande Biotechnology Co., Ltd ibisebenza ngokukhethekile ekukhiqizenipaclitaxel APIiminyaka engaphezu kwengu-20, futhi ingomunye wabakhiqizi abazimele bezwe be-paclitaxel API, umuthi olwa nomdlavuza osuselwe esitshalweni, ogunyazwe yi-US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan kanye nezinye izinhlaka ezilawula izwe. .I-Hande ayikwazi ukunikeza izinga eliphezulu kuphelapaclitaxel izinto zokusetshenziswa,kodwa futhi nezinsizakalo zokuthuthukisa ezobuchwepheshe ezihlobene ne-paclitaxel formulation.Ngolwazi olubanzi, sicela ukhululeke ukusithinta ku-18187887160.