Kulo mfutho ophakeme, isigqi esiphezulu kanye nemvelo egelezayo yokugeleza, abanye abantu bavame ukubambezela isikhathi sabo sokulala ebusuku, okwenza kube nzima ukulala, okuholela kwezinye izinkinga zokulala. Yini okufanele siyenze? Uma kunenkinga, kuyoba nzima kube yindlela yokuxazulula inkinga.
Okwamanje lapho abantu abaningi bezwai-melatonin,bacabanga ukuthi i-melatonin iwumkhiqizo wobuhle.Eqinisweni, i-melatonin iyi-hormone yangaphakathi eyenza ubuthongo bemvelo.Inqoba izithiyo zokulala futhi ithuthukise izinga lokulala ngokulawula ukulala kwabantu okungokwemvelo.Emakethe, iwumkhiqizo wokunakekelwa kwezempilo othandwa kakhulu ukusiza ukulala.
Ngokwezibalo ze-World Health Organization, izinga lokuphazamiseka kokulala emhlabeni lingama-27%, osekuphenduke okwesibili ukuphazamiseka kwengqondo okuvame kakhulu emhlabeni. Umbiko okhishwe yinhlangano ecwaninga ngokulala yaseChina ukhombisa ukuthi abantu abangaphezu kwezigidi ezingu-300 eChina banezinkinga zokulala, kuyilapho izinga lokuqwasha kubantu abadala lifinyelela ku-38.2%.
Ngakho ingabe i-Melatonin ingasiza ngempela ukulala?Inamuphi umphumela?
###Ake sibheke i-melatonin nendima yayo.
I-Melatonin(MT) ingenye yamahomoni akhiqizwe yi-pineal gland.I-Melatonin iyingxenye ye-indole heterocyclic compounds.Igama layo lekhemikhali i-N-acetyl-5 methoxytryptamine, eyaziwa nangokuthi i-pinealoxin.Ngemva kwe-melatonin synthesis, igcinwa ku-pineal gland. Ukujabula okuzwelayo kuphazamisa amaseli endlala kaphayini ukuze akhulule i-melatonin. Ukukhiqizwa kwe-melatonin kunesigqi esisobala sokujikeleza, esivinjelwa emini futhi sisebenze ebusuku.
I-Melatonin ingavimbela i-hypothalamic pituitary gonadal axis, yehlise okuqukethwe kwehomoni ekhipha i-gonadotropin, i-gonadotropin, i-luteinizing hormone kanye ne-follicular estrogen, futhi isebenze ngokuqondile kuma-gonads ukuze kuncishiswe okuqukethwe kwe-androgen, i-estrogen ne-progesterone. Ucwaningo lwakamuva lubonisa ukuthi i-melatonin iyi-hormone umkhuzi oyinhloko we-endocrine.Ilawula imisebenzi yezindlala ezihlukahlukene ze-endocrine emzimbeni, ngaleyo ndlela ilawula ngokungaqondile ukusebenza kwawo wonke umzimba wethu.
Umsebenzi kanye Nokulawulwa kwe-Melatonin
1) Lungisa isigqi se-circadian
Ukwengeza i-melatonin evela ngaphandle komzimba kungagcina izinga le-melatonin emzimbeni usemncane, kulungise futhi kubuyisele isigqi se-circadian, kungagcini nje ngokujulisa ukulala futhi kuthuthukise izinga lokulala, kodwa futhi kuthuthukisa isimo sokusebenza kwe-circadian. umzimba wonke,ithuthukisa izinga lempilo futhi ibambezele inqubo yokuguga.Ngenxa yokuthi ngokukhula kweminyaka, indlala yepineal iyashwabana ize ibalwe, okuholela ekubeni buthakathaka noma ukushabalala kwesigqi sewashi lezinto eziphilayo.Ikakhulukazi ngemva kweminyaka engu-35 ubudala, i-melatonin ekhiqizwa umzimba iyancipha kakhulu, ngokuncipha kwesilinganiso ngo-10 ~ 15% njalo eminyakeni eyi-10, okuholela ekuphazamisekeni kokulala kanye nochungechunge lwezinkinga zokusebenza. ukuguga.
2) Ukuguga ukubambezeleka
I-pineal gland yabantu asebekhulile iyancipha kancane kancane, futhi ukukhishwa kwe-MT kuyehla ngokufanele.Inani leMel elidingwa izitho ezihlukahlukene emzimbeni alanele, okuholela ekugugeni nasezifo.Ososayensi babiza i-pineal gland iwashi lokuguga komzimba.Uma sengeza MT ngaphandle, singabuyisela emuva iwashi eliguga.
3) Vimbela izilonda
Ngenxa yokuthi i-MT ingangena kalula kumaseli, ingasetshenziswa ukuvikela i-nuclear DNA.Uma i-DNA yonakele, ingase iholele emdlavuza.Uma kukhona i-Mel eyanele egazini, akulula ukuthola umdlavuza.
I-4) Umphumela wokulawula ohlelweni lwezinzwa oluphakathi
Inani elikhulu lezifundo zomtholampilo nezokuhlola libonisa ukuthi i-melatonin, njengehomoni ye-neuroendocrine engapheli, inokulawula okuqondile nokungaqondile kokusebenza komzimba ohlelweni lwezinzwa olumaphakathi, imiphumela yokwelapha ezinkingeni zokulala, ukucindezeleka nezifo zengqondo, kanye nemiphumela yokuvikela kumaseli ezinzwa. ,i-melatonin inomphumela wokulalisa, ingakwazi futhi ukwelapha ukucindezeleka kanye nengqondo, ingavikela izinzwa, ingadambisa ubuhlungu, ilawule amahomoni akhishwa i-hypothalamus nokunye.
5) Ukulawulwa kwamasosha omzimba
Eminyakeni eyishumi yamuva nje, umphumela olawulayo we-melatonin esimisweni somzimba sokuzivikela ezifweni udonse ukunaka okusabalele. Ucwaningo olwenziwa ekhaya naphesheya luye lwabonisa ukuthi i-melatonin ayithinti nje kuphela ukukhula nokuthuthukiswa kwezitho zokuzivikela, kodwa futhi ilawula ukungatheleleki kwe-humoral, ukungatheleleki kwamaselula nama-cytokines. Isibonelo, i-melatonin ingalawula ukungatheleleki kwamaselula kanye ne-humoral, kanye nomsebenzi wezinhlobonhlobo zama-cytokines.
6) Umphumela wokulawula ohlelweni lwenhliziyo
Umsebenzi wesimiso semithambo unesigqi esisobala se-circadian nesigqi sesizini, okuhlanganisa umfutho wegazi, izinga lokushaya kwenhliziyo, ukuphuma kwenhliziyo, i-renin angiotensin aldosterone, njll.Izinga lokuphuma kwe-melatonin ku-serum yegazi lingabonisa isikhathi esihambisanayo sosuku kanye nenkathi ehambisanayo yonyaka. .Ngaphezu kwalokho, imiphumela yokuhlola efanele yaqinisekisa ukuthi ukwanda kokuphuma kwe-MT ebusuku kwakuhlobene kabi nokuncipha komsebenzi wenhliziyo nemithambo yegazi; I-Pineal melatonin ingavimbela ukungezwani komzimba okubangelwa ukulimala kwe-ischemia-reperfusion, ithinte ukulawulwa komfutho wegazi, ilawule ukugeleza kwegazi lobuchopho, futhi lawula ukusebenza kabusha kwemithambo ye-peripheral ku-norepinephrine.
7) Ngaphezu kwalokho, i-melatonin iphinde ilawule uhlelo lokuphefumula lomuntu, uhlelo lokugaya ukudla kanye nohlelo lokuchama.
Isiphakamiso se-Melatonin
i-melatoninakuwona umuthi.Kungadlala indima eyisizayo kuphela ekuqwaleni futhi akunawo umphumela wokwelapha.Ngezinkinga ezinjengokungalali kahle nokuvuka phakathi nendawo, ngeke kube nomphumela obalulekile wokuthuthuka.Kulezi zimo, kufanele uthole ukwelashwa ngesikhathi futhi uthole ukwelashwa okufanele kwezidakamizwa.
Uyafuna ukwazi okwengeziwe nge-melatonin?I-Hande izimisele ukuhlinzeka amakhasimende ngemikhiqizo engcono nenempilo ekhishwayo.Sihlinzeka ngemikhiqizo ye-melatonin yekhwalithi ephezulu nesezingeni eliphezulu ukuze ikusize uthuthukise ukulala kwakho futhi uphile kahle nsuku zonke!
Isikhathi sokuthumela: May-11-2022