Izici ze-albumin-bound paclitaxel, i-Anticancer Drug

I-Paclitaxel iwumkhiqizo wemvelo okhishwe ku-Taxus, osebenza ku-tubulin ukuvimbela i-mitosis yamaseli wesimila.Kuze kube manje, i-paclitaxel iyisidakamizwa semvelo esihle kakhulu sokulwa nomdlavuza esitholakele. ukusebenza kahle komtholampilo ekwelapheni umdlavuza webele, umdlavuza wesibeletho, umdlavuza wamaphaphu ongewona omncane, umdlavuza we-gastroesophageal nezinye izimila.

Ngenxa yokuthi i-paclitaxel yendabuko ine-lipophilic kakhulu, futhi isithako esisebenzayo kunzima ukuncibilika emanzini, i-ethanol anhydrous, i-polyoxyethylene castor oil, njll. isetshenziswa ekulungiseni inqubo ukuyisiza incibilike. futhi ezimeni ezimbi kakhulu, kungase kwenzeke ukushaqeka kwe-anaphylactic, okubeke ukuphila engozini. Izehlakalo zokungezwani komzimba ziphakeme kakhulu njengoba zifinyelela ku-20% -40%. Ukuze kuvinjwe ngempumelelo, ukwelashwa kusengaphambili nge-corticosteroids nama-antihistamine kufanele kwenziwe ngaphambi kokuphathwa. I-Paclitaxel idinga ukuhlanjululwa umthamo omkhulu ngaphambi kokujova ngomjovo, futhi isikhathi sokumnika sidinga ukugcinwa okungenani amahora ama-3.

Ukuze sinqobe lesi sici, kwaba khona i-paclitaxel eboshwe nge-albumin.I-paclitaxel eboshwe nge-albumin ihlanganisa i-hydrophobic paclitaxel ne-albumin ukuze kwakheke ama-nanoparticles anosayizi wezinhlayiyana ezingaba ngu-130 nm ngokusebenzisa i-nanotechnology.Isebenzisa indlela yokuthutha yemvelo eyingqayizivele i-albumin ukwenza i-paclitaxel isabalaliswe kakhudlwana ezicutshini zesimila futhi ifinyelele ukugcwala okuphezulu kumaseli wesimila; igwema ukusetshenziswa kwe-ethanol anhydrous, i-polyoxyethylene castor oil nezinye izinto ezincibilikayo, inciphisa kakhulu ukuvela kokungezwani komzimba, futhi ayidingi ukwelashwa okulwa nokungezwani komzimba ngaphambi kokusetshenziswa. ,futhi ayidingi ukusebenzisa idivayisi ekhethekile yokumnika.Ukumnika kungaqedwa ngesigamu sehora.Ifeza ngempela umphumela ophezulu wokwelapha kanye nobuthi obuphansi.

Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezethulwe kulesi sihloko konke kuvela ezincwadini ezishicilelwe.

I-Yunnan Hande Biotechnology Co., Ltd ibisebenza ngokukhethekile ekukhiqizenipaclitaxel APIiminyaka engaphezu kwengu-20, futhi ingomunye wabakhiqizi abazimele bezwe be-paclitaxel API, umuthi olwa nomdlavuza osuselwe esitshalweni, ogunyazwe yi-US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan kanye nezinye izinhlaka ezilawula izwe. .I-Hande ayikwazi ukunikeza izinga eliphezulu kuphelapaclitaxel izinto zokusetshenziswa,kodwa futhi nezinsizakalo zokuthuthukisa ezobuchwepheshe ezihlobene ne-paclitaxel formulation.Ngolwazi olubanzi, sicela ukhululeke ukusithinta ku-18187887160.