I-paclitaxel ilwa kanjani nomdlavuza?

I-Paclitaxel iyi-diterpenoid ekhishwe ohlotsheni lwe-Taxus Taxus, futhi ososayensi bathole ukuthi inomsebenzi oqinile we-antitumor ekuhlolweni kokuhlolwa.Okwamanje,paclitaxelisetshenziswa kakhulu ekwelapheni umdlavuza webele, umdlavuza wesibeletho, umdlavuza wamaphaphu ongewona omncane, umdlavuza wamaphaphu, umdlavuza womminzo, umdlavuza wesisu, isimila sekhanda nentamo, izicubu ezithambile sarcoma nezinye izimila ezimbi, futhi ingenye evame kakhulu wasebenzisa izidakamizwa ze-chemotherapy ekusebenzeni komtholampilo.Ngakho-ke i-paclitaxel ilwa kanjani nomdlavuza?Ake sibheke ngezansi.

I-paclitaxel ilwa kanjani nomdlavuza?Kuyaziwa ukuthi ngesikhathi sokuhlukaniswa kwamaseli okuvamile, ingqamuzana ihlukaniswe izingxenye ezimbili.Ngemva kokuba i-chromosome isiphindaphindekile, umcu wokuphotha uyawudonsa usuka endaweni yawo yokuqala uwuyise ezinhlangothini zombili, futhi i-spindle idinga ukukhishwa kwe-polymerization yama-microtubules njengokwakheka kwe-cytoskeleton, ama-Chromosome angaqeda i-mitosis kuphela ngokuthuthela ezigxotsheni ezingaphansi kokudonsa kokuphotha futhi. i-spindle filament, ngakho-ke ama-microtubules abaluleke kakhulu ekuhlukaniseni kwamaseli.

Ngo-1979, usokhemisi uHorwitz wathola lokhopaclitaxelingakwazi ukubopha ku-tubulin futhi ikhuthaze i-polymerization ye-tubulin ukuze yakhe ama-microtubules, ngaleyo ndlela ivimbele ukuhlukaniswa okujwayelekile komzimba kwama-microtubules, okwenza ingakwazi ukwenza ama-spindles kanye ne-spindle filaments, okwenza amangqamuzana Ukungakwazi ukuhlukanisa ngokuvamile kuvimbela ukukhiqizwa okusheshayo kwamangqamuzana omdlavuza futhi kubangele i-apoptosis. yamangqamuzana omdlavuza.Ngakho-ke, phakathi kwezidakamizwa ezilwa nomdlavuza, i-paclitaxel ithathwa njenge-microtubule inhibitor ku-mitosis.

Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezichazwe kulesi sihloko kuthathwe ezincwadini ezishicilelwe.

Ukufunda okunwetshiwe:I-Yunnan Hande Biotechnology Co., Ltd. ibigxile ekukhiqizweni kwe-paclitaxel iminyaka engama-28.Ingumkhiqizi wokuqala ozimele emhlabeni womuthi we-anticancer osuselwa esitshalweni ugunyazwe yi-US FDA, European EDQM, Australian TGA, China CFDA, India, Japan kanye nezinye izikhungo zokulawula zikazwelonke.ibhizinisi.Uma ufuna ukuthengaI-Paclitaxel API,sicela usithinte ku-inthanethi.