Yenziwa kanjani i-Semi-synthetic paclitaxel?

I-Paclitaxel, isidakamizwa semvelo sokulwa nomdlavuza, sikhishwe ikakhulukazi ku-Taxus chinensis.Isetshenziswe kakhulu ekwelapheni umdlavuza webele, umdlavuza wesibeletho, kanye nomdlavuza wekhanda nentamo kanye nomdlavuza wamaphaphu ngokomtholampilo.I-Paclitaxel ihlukaniswe ngokwemvelo.paclitaxelfuthiI-semi-synthetic paclitaxel.Ngezansi, ake sibheke ukuthi i-Semi-synthetic paclitaxel yenziwa kanjani.

Njengoba i-paclitaxel yemvelo ikhishwa ku-Taxus chinensis enemithombo embalwa, futhi umjikelezo wokukhula kwe-Taxus chinensis yemvelo mude, cishe amagxolo angu-13.6kg kuphela angakhipha i-1g ye-paclitaxel, futhi kuthatha izihlahla ze-taxus ezi-3 kuye kweziyi-12 ezinomlando weminyaka engaphezu kweyi-100. ukwelapha isiguli somdlavuza wesibeletho, ukushoda kwesikhathi eside kokuhlinzekwa kanye nentengo ephezulu kwenza ubuchwepheshe bokwenziwa kokwenziwa kwe-paclitaxel bukhule ngokushesha.

Njengento ekhishwe ezitshalweni zemvelo, i-paclitaxel inesakhiwo esiyinkimbinkimbi.Nokho, ukuze kubhekwane nokushoda kwezinto ezingavuthiwe, osokhemisi abavela emhlabeni wonke bacwaninga ukuhlanganiswa kwe-paclitaxel. Kwaze kwaba yilapho usokhemisi ongumFulentshi ehlukanisa into ebizwa ngokuthi.10-DABkusukela emaqabunga e-British Taxus chinensis, ukwakheka kwayo kwakufana kakhulu ne-paclitaxel, futhi okuqukethwe kwayo kwakuphakeme.Amaqabunga ayevuselela ngaphezu kwamagxolo namagatsha, futhi ayenomonakalo omncane ku-Taxus chinensis.

Ngemizamo engapheli yososayensi, indlela yokuI-semi-synthetic paclitaxelekugcineni yathuthukiswa, futhi akusadingeki ukuba kunqunywe i-Taxus chinensis ukuze ikhishwe. Ngemva kwalokho, ngokufunda ukwakheka kwe-paclitaxel, kwasungulwa eminye imithi yamakhemikhali efana ne-docetaxel ne-albumin paclitaxel, iletha imithi yokwelapha eyengeziwe ezigulini ezinomdlavuza.

Incazelo: Ukusebenza okunamandla kanye nezinhlelo zokusebenza ezishiwo kulesi sihloko konke kuvela ezincwadini ezitholakala esidlangalaleni.

Ukufundwa okunwetshiwe:I-Hande Bio-tech igxile kakhulu ekukhishweni nasekuthuthukisweni kwe-taxane.Imikhiqizo yayo eyinhloko i-paclitaxel yemvelo, i-10-DAB Semi-synthetic paclitaxel,10-DABIII,docetaxel,cabataxel,njll.Uma udinga ukwazi nge-paclitaxel ama-API asekelwe, sicela ukhululeke ukuxhumana nathi.