I-Natural Paclitaxel VS Semi-synthetic Paclitaxel (I)

Umuthi Wedivayisi

I-Paclitaxel, njengesidakamizwa esilwa nomdlavuza, isetshenziswa kabanzi kuma-Injection namadivaysi ahlukahlukene.

Ngokuyinhloko yenziwa isizinda semvelo kanye nokuhlanganiswa.

Njengomthombo wesitshalo we-paclitaxel ekhishwe ngokwemvelo, i-Taxus Chinensis, iyindlala futhi inomjikelezo omude wokukhula, uchungechunge lwezindlela zokuhlanganisa luthathwe kancane kancane ku-paclitaxel ngocwaningo nokuhlola emhlabeni jikelele, okuhlanganisa ukuhlanganisa okuphelele, i-semi-synthesis, kanye i-endophytic synthesis.

Ngenxa yendlela ende yokuhlanganiswa kwamakhemikhali, izinyathelo eziningi zokuhlanganisa, futhi kunzima ukulawula izimo zokusabela, i-paclitaxel ehlanganiswe ngokugcwele idinga ukusebenzisa ama-reagents amakhemikhali abiza kakhulu, futhi isivuno siphansi, esingafanelekile ukukhiqizwa ngobuningi nokukhiqizwa kwezimboni jikelele.

Ngakho-ke, inani elikhulu kakhulu le-paclitaxel emakethe ngokuvamile lenziwa ngokukhipha imvelo kwe-taxus etshaliwe kanye nezindlela zokwenziwa kwe-semi-synthetic.

I-Paclitaxel Yemvelo vs I-Semi-synthetic Paclitaxel

Ingxenye 1:Inqubo Yokukhiqiza

I-paclitaxel yemvelo:

-Impahla eluhlaza:I-Yew etshalwe ngokuzenzakalelayo

-Inqubo yokukhipha:impahla eluhlaza+ikholomu chromatography+recrystallization=umkhiqizo oqediwe

-Inqubo yokukhipha: ukusabela ngokomzimba, akukho nqubo yamakhemikhali

I-Semi-synthetic Paclitaxel:

-Impahla eluhlaza:I-Yew etshalwe ngokuzenzakalelayo

-Inqubo yokukhipha:izinto ezingavuthiwe+i-chemical reagent reaction+i-crystallization egxilile+ukusabela kwamakhemikhali okuhlukahlukene+recrystallization=umkhiqizo oqediwe

-Inqubo yokukhipha:ukusabela kwamakhemikhali

Mayelana nobuchwepheshe, i-paclitaxel yemvelo inezinyathelo ezilula zokukhipha uma kuqhathaniswa ne-semi-synthetic paclitaxel kanye nezinzuzo ezengeziwe ngaphezu kwe-semi-synthetic paclitaxel mayelana nokuzinza nokuphepha, kuyilapho i-semi-synthetic paclitaxel yehlisa izindleko zokuthuthukiswa komkhiqizo mayelana nezindleko nezinto zokusetshenziswa. ,futhi iphinde ithuthukise ezinye izinkinga ezibangelwa ukushoda kwezinto ezingavuthiwe emakethe.

Uma kuqhathaniswa nezindlela ezimbili zokukhiqiza i-paclitaxel, i-paclitaxel yemvelo inokuqina nokuphepha okungcono emishinini yezokwelapha, okuyisizathu esisodwa esenza izinkampani eziningi zemishini yezokwelapha emakethe zisebenzisa i-paclitaxel yemvelo njengempahla eluhlaza.

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