I-Natural Paclitaxel VS Semi-synthetic Paclitaxel(II)

I-Yew taxus chinensis extract ikhishwa ezitshalweni eziyivelakancane, ezibekiwe, isiqu, isikhumba, impande iqukethe izithako eziyinhloko yilezi:i-yew alkali diterpenoid compounds,yew ning A kanye ne-yew,yew ning H,yew,yew ning K,l,yew alkali, i-jinsong yellow ketone,i-slope eshiya u-A,le ketone eshiya i-ketone,i-jinsong ephindwe kabili yeketone ephuzi,i-naphtha,yew,i-polysaccharide,i-tannins,ibomvu elishukiwe, njll.,ingase futhi ibe namanye ama-polyphenols,ama-amino acid,i-wood resin,izakhi ezingaphili.I-Paclitaxel ine anti-leukemia kanye nemiphumela yesimila.

I-Paclitaxel, esizokhuluma ngayo, iyisidakamizwa esihle kakhulu semvelo sokulwa nomdlavuza esatholakala kuze kube manje.Isetshenziswe kakhulu ekwelapheni umdlavuza webele, umdlavuza wesibeletho, umdlavuza wekhanda nentamo, umdlavuza wamaphaphu kanye nokunye okuningi. eminye imidlavuza ngokomtholampilo.

I-Paclitaxel Yemvelo vs I-Semi-synthetic Paclitaxel

Ukungcola:

I-paclitaxel yemveloikhishwa ezimpandeni, eziqwini nasemaqabungeni e-Taxus chinensis.Ngemva kwekholomu chromatography kanye ne-recrystallization, yonke le nqubo iwukukhipha umzimba nokuhlanzwa ngaphandle kokusabela kwamakhemikhali.Ukungcola okuqukethwe kuyo kuvela ezithakweni zesitshalo ngokwaso, futhi akukho ukungcola. elethwe yi-chemical synthesis.Ngakho-ke, ukulungiswa kokungcola kwe-paclitaxel yemvelo kufundwa ngokugcwele futhi kuyalawuleka nakakhulu okwamanje.

I-semi-synthetic paclitaxelinokwakheka kwamakhemikhali amaningi kunawemvelo enqubweni yayo, futhi imithombo yayo yokungcola nayo ingaphezu kweyemvelo, kuhlanganisa naleyo ekhishwe ezitshalweni, nokunye ukungcola okukhiqizwa ngenxa yokusabela kwamakhemikhali. ukungcola okungaba khona.Kule nqubo, inani kanye nohlobo lokungcola kuhlala kuguquguquka.Ngakho-ke, i-semi-synthetic paclitaxel inokulawuleka okuphansi kokungcola, futhi ukungcola okusha kudinga ukuhlolwa njalo lapho kwenziwa inqubo yokukhiqiza.Ukungcola okukhiqizwa izinqubo ezahlukene zokukhiqiza nakho kuyafaneleka. ehluke kakhulu, futhi ukuhlaziya okuqondile kuyadingeka.

I-Yunnan Hande Bio-Tech ibambe iqhaza ekukhishweni nasekuthuthukisweni kwentela iminyaka engama-30, futhi imikhiqizo yayo eyisisekeloi-paclitaxel yemvelo,10-DAB semi-synthetic paclitaxel,10-deacetylbaccatin III,docetaxel,cabazitaxel,etc.Ukuze uthole ulwazi olwengeziwe mayelana ne-paclitaxel APIs,sicela usithinte!!!(Whatsapp/Wechat:+86 18187887160)