I-Paclitaxel iwuketshezi olukhishwe ku-yew, olunganqanda ngempumelelo umdlavuza futhi iyisidakamizwa esilwa nomdlavuza esisetshenziswa kabanzi emhlabeni. Ngeminyaka yawo-1960, osokhemisi baseMelika bahlukanisa i-taxol egxolweni le-Pacific yew, isitshalo se-Taxus. Ngemva kweminyaka engaphezu kwengu-20 ucwaningo lwezempilo, umjovo wokuqala we-paclitaxel "Taxol" wethulwa ngo-1992. Kuze kube manje,paclitaxelingenye yemithi eyaziwayo ye-botanical anti-tumor esebenza kahle.Inezici zokusebenza kahle kakhulu, ubuthi obuphansi kanye ne-spectrum ebanzi.Inemiphumela esobala yokwelapha kumdlavuza wesibeletho, umdlavuza webele, i-melanoma eyingozi, umdlavuza wamaphaphu, umdlavuza wendlala yesinye, ubuchopho. umdlavuza kanye nomdlavuza we-colorectal.
Imiphumela yokuhlolwa kwezokwelapha ibonisa ukuthi, okwamanje, ukutholwa kwepaclitaxel APIsikakhulukazi kuncike ekukhishweni kwezitshalo ze-Taxus chinensis namakhemikhali aSemisynthesis.Abacwaningi besayensi baqoqa amagatsha alinywe ngokuzenzela kanye namaqabunga e-Taxus chinensis chinensis,sebenzisa i-solvent extraction,isigaba esiqinile sokukhipha uketshezi,ukuhlukaniswa kwe-membrane,ukuhlukaniswa kwe-chromatographic nezinye izindlela zokuhlukanisa nezindlela zokukhipha khipha izandulela ezifana nesakhiwo se-paclitaxel,njenge-bacatine III,10 i-deacetyl bacatine III, njll.,bese uthola izidakamizwa eziyinqwaba ye-paclitaxel yezokwelapha ngokuguqulwa kwamakhemikhali kwezindlela zokukhiqiza ngobuningi.
Ngokwezibalo zososayensi, iziguli ezinomdlavuza zidinga ukudla okungaphezu kwamagremu angu-2paclitaxelngenkambo eyodwa yokwelashwa. Le mikhondo ye-paclitaxel idinga ukukhishwa egxolweni lezihlahla ze-Taxus chinensis zasendle ezingu-4-8 ezikhule iminyaka engaphezu kwengu-50. Ngakolunye uhlangothi, i-Taxus chinensis ne-paclitaxel ziyindlala, kanti Ngakolunye uhlangothi, kunesidingo esikhulu sokwelashwa, esiholela enanini eliphezulu lezinto zokusetshenziswa ze-Taxus chinensis unyaka wonke, futhi ukunikezwa kuyasilela.
Incazelo: Ukusebenza okunamandla kanye nezinhlelo zokusebenza ezishiwo kulesi sihloko konke kuvela ezincwadini ezitholakala esidlangalaleni.
Ukufundwa okunwetshiwe:I-Yunnan Hande Bio-tech ibambe iqhaza kakhulu ekukhishweni nasekuthuthukisweni kwe-taxane.Imikhiqizo yayo ewumongo i-Paclitaxel,10-DAB Semisynthesis Paclitaxel,10-DABIII,docetaxel,cabataxel,njll.Uma udinga ukwazi nge-paclitaxel based izinto zokusetshenziswa, sicela ukhululeke ukuxhumana nathi ku.
Isikhathi sokuthumela: Jun-14-2023