I-Paclitaxel iwumkhiqizo wemvelo ohlukanisiwe futhi wahlanzwa egxolweni, ezimpandeni eziqinile, amaqabunga, amahlumela nezithombo zesihlahla se-redbud, ezinokuqukethwe okuphezulu kakhulu emagxolweni.I-Paclitaxelisetshenziselwa ikakhulukazi umdlavuza wesibeletho nowebele, kodwa futhi iyasebenza kumdlavuza wamaphaphu, umdlavuza we-colorectal, i-melanoma, umdlavuza wekhanda nentamo, i-lymphoma kanye nesimila sobuchopho. Ake sibheke umuthi we-paclitaxel wemvelo wokulwa nomdlavuza esihlokweni esilandelayo.
I-Paclitaxel isetshenziswa kabanzi ekwelapheni umdlavuza wamaphaphu, umdlavuza webele, umdlavuza wesibeletho, umdlavuza wekhanda nentamo, umdlavuza wesisu kanye nezinye izimila eziyingozi. ,ukuhlanganiswa kwe-microtubule futhi kuvimbele ukuchithwa kwe-depolymerization, ngaleyo ndlela kuzinzisa ama-microtubules futhi kuvimbele i-mitosis futhi kubangele i-apoptosis yamangqamuzana omdlavuza, ngaleyo ndlela kumise ngempumelelo ukwanda kwamangqamuzana omdlavuza futhi kudlale indima yokulwa nomdlavuza.
Sekuyiminyaka ecishe ibe ngu-30 kusukela ngaleso sikhathipaclitaxelyathengiswa ngo-1992.Ngenxa yokusebenza kwayo okunembayo, izinkomba ezibanzi kanye nesidingo esikhulu somtholampilo, ucwaningo nokuthuthukiswa kwezinhlobo zemithamo ezithuthukisiwe ze-paclitaxel kuqhubekile, futhi amafomu omthamo we-paclitaxel adayisiwe ahlanganisa umjovo ovamile we-paclitaxel,paclitaxelI-liposome kanye ne-albumin paclitaxel.Imikhiqizo ye-paclitaxel okwamanje ingamakhemikhali asezingeni eliphezulu e-China ngokwenani lokuthengisa, futhi futhi inkulu ngokwenani lokuthengisa emkhakheni wezidakamizwa ezilwa nesimila.
Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezichazwe kulesi sihloko kuvela ezincwadini ezishicilelwe.
Isikhathi sokuthumela: Jun-13-2023