Umshini wokulwa nomdlavuza we-Paclitaxel. Yini oyaziyo?

I-Paclitaxel iyisidakamizwa esilwa nomdlavuza esisetshenziselwa ukwelapha izinhlobo eziningi zomdlavuza.Yaqala yakhishwa egxolweni lesihlahla se-yew sasePacific (i-Taxus pacifica) futhi kamuva yakhiqizwa ngezindlela zokwenziwa.I-Paclitaxelingeyeqembu lezidakamizwa ezibizwa ngokuthi i-microtubule stabilizers.

Indlela yokulwa nomdlavuza yepaclitaxelkuhlanganisa izici eziningi, ikakhulukazi ezihlanganisa lokhu okulandelayo:

I-1.Ukuqina kwe-microtubule: I-Paclitaxel ivimbela ukuzinza okujwayelekile okuguquguqukayo kwama-microtubules ngokubophezela ku-tubulin, eyingxenye ye-cytoskeleton.Lokhu kubangela ukuthi ama-microtubules ahluleke ukubhidlika futhi ahlele kabusha, avimbele ukuhlukana nokukhula kwamangqamuzana. isici esiyinhloko somdlavuza, ngakho-ke ukuvimbela ukuhlukana kwamaseli ngokuzinzisa ama-microtubules kuyindlela eyinhloko ye-anticancer ye-paclitaxel.

I-2.Ukuboshwa komjikelezo wamaseli:I-Paclitaxel ingabangela nokuboshwa komjikelezo weseli, okubangela ukuthi amangqamuzana omdlavuza amise esigabeni esithile somjikelezo weseli, ngokuvamile i-mitosis.Lokhu kusiza futhi ukubambezela ukukhula nokuhlukaniswa kwamaseli omdlavuza.

3.Ithuthukisa i-apoptosis:I-Paclitaxel ingase ivimbele ukukhula komdlavuza ngokukhuthaza amaseli omdlavuza owonakele noma ongajwayelekile ukuthi angene ku-apoptosis(ukufa kweseli okuhleliwe).Lena inqubo yemvelo yokufa kwamaseli esiza ukususa amaseli angavamile.

4. I-Anti-angiogenesis:I-Paclitaxelfuthi ingavimbela ukwakheka kwemithambo yegazi emisha ezungeze amangqamuzana omdlavuza, okudingekayo ekukhuleni kwesimila futhi sisakazeke.Ngokuvimbela ukwakheka kwemithambo yegazi emisha, kunganciphisa ukutholakala kwegazi esimila, ngaleyo ndlela kunciphise ukukhula kwesimila.

Sekukonke, i-paclitaxel iyisidakamizwa esiphazamisa ukukhula nokuhlukana kwamangqamuzana omdlavuza, asebenza kumaseli omdlavuza ngokusebenzisa izindlela ezahlukahlukene, futhi ngenxa yalokho asetshenziswa kabanzi ezinhlotsheni eziningi zokwelashwa komdlavuza.

Qaphela:Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.

I-Yunnan Hande Biotechnology Co., Ltd. igxile ekukhiqizenipaclitaxeliminyaka engu-26, futhi ungumkhiqizi ozimele we-anti-cancer drug paclitaxel API ekhishwe esitshalweni egunyazwe yi-United States FDA,European EDQM,Australia TGA,China CFDA,India,Japan kanye nezinye izinhlaka zokulawula zikazwelonke.Yunnan Hande paclitaxel,spot supply ,ukuthengiswa okuqondile kwasefekthri, siyakwamukela ukubuza,18187887160(WhatsApp inombolo efanayo)