Inqubo yokukhiqiza ye-Paclitaxel, isidakamizwa esisetshenziswa kakhulu ekwelapheni umdlavuza, iyinqubo eyinkimbinkimbi futhi eyinkimbinkimbi ehlanganisa izinyathelo eziningi, kusukela ekukhishweni okuvela emithonjeni yemvelo kuya ekwakhiweni kokugcina kwemithi.Leli phepha lizokwethula inqubo yokukhiqizapaclitaxel, kusukela ekukhishweni kuya ekulungiseni.
Isinyathelo 1: Khipha
I-Paclitaxelekuqaleni yakhishwa egxolweni lesihlahla se-yew sasePacific, i-Taxus pacifica.Inqubo iqala ngokuqoqwa kwamagxolo futhi ngokuvamile idinga ukuphathwa ngokucophelela ukugwema ukulimala esihlahleni.Amagxolo aqoqiwe abe esephulwa futhi afakwe ku-solvent efanele, njenge-ether noma i-xylene.I-Paclitaxel incibilika isuka egxolweni ibe yincibilikisi kulesi sinyathelo ukuze yakhe i-extract.
Isinyathelo sesi-2: Ukwehlukana
Izingcaphuno zivame ukuqukatha izinhlobonhlobo zezinhlanganisela ezahlukene, ngakho-ke i-paclitaxel idinga ukuhlukaniswa kwezinye izinhlanganisela.Lesi sinyathelo ngokuvamile sisebenzisa i-chromatographic chromatography noma amanye amasu okuhlukanisa ukuze ahlukanise i-paclitaxel kwezinye izinto ngokusekelwe kuzakhiwo zenhlanganisela.
Isinyathelo sesi-3: Ukuhlanzwa
I-paclitaxel ehlukanisiwe idinga ukuhlanzwa ngokwengeziwe ukuze kususwe noma yikuphi ukungcola okusele futhi ithole umkhiqizo omsulwa kakhulu.Lokhu kuvame ukubandakanya izinyathelo ezinjengokucwebezela, ukucwenga, kanye nokwenza kabusha ikristalu ukuze kuqinisekiswe ukuthi i-paclitaxel yokugcina imsulwa.
Isinyathelo sesi-4: I-synthesis (kuyakhetheka)
Nakuba i-paclitaxel yasekuqaleni yakhishwa emithonjeni yemvelo, izinkampani eziningana ezithaka imithi zenze izindlela zokuyihlanganisa.Lezi zindlela zisebenzisa izindlela zamakhemikhali zokwenziwa ukwandisa isivuno nokulawula kanye nokunciphisa ukuncika emithonjeni yemvelo.
Isinyathelo sesi-5: Lungisa umuthi
Isinyathelo sokugcina senqubo yokukhiqiza ukulungiswa kwe-paclitaxel ehlanzekile ibe ukulungiselela ukusetshenziswa kwezokwelapha.Lokhu kungase kuhlanganise ukuncibilikisa i-paclitaxel kusinyibilikisi esifanelekile, esifana notshwala noma i-ether, ukuyilungiselela ibe isilungiselelo somuthi.Ifomu elivame kakhulu lilungiswa njengekhambi lomjovo ukuze kuqinisekiswe umthamo oqondile.
Kuhlanganiswe, inqubo yokukhiqizapaclitaxelkuyinqubo eyinkimbinkimbi futhi enezinyathelo eziningi eklanyelwe ukuqinisekisa ubumsulwa nokulawulwa komuthi wokugcina.Impumelelo yale nqubo ibalulekile ekulethweni kokwelashwa komdlavuza okusebenzayo ngakho-ke ihlale ithuthukiswa futhi ithuthukiswa ukuze ihlangabezane nezidingo zezokwelapha.
Qaphela: Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.
I-Yunnan Hande Biotechnology Co., Ltd. ibigxile ekukhiqizeni i-paclitaxel iminyaka engu-26, futhi ingumkhiqizi ozimele we-anti-cancer drug paclitaxel API ekhishwe esitshalweni egunyazwe yi-United States FDA, European EDQM, Australia TGA, China CFDA , India, Japan kanye nezinye izinhlaka zokulawula zikazwelonke.Yunnan Hande paclitaxel, spot supply, factory direct sales, wamukelekile ukubuza, 18187887160 (WhatsApp inombolo efanayo)
Isikhathi sokuthumela: Oct-13-2023