I-Paclitaxel iwumkhiqizo wemvelo oyinkimbinkimbi onomsebenzi oqinile we-antitumor.Ngenxa yemininingwane nobunkimbinkimbi besakhiwo sayo.kubalulekile ukulawula ngokuqinile ukulawulwa kwekhwalithi namazingapaclitaxel.Ukulawulwa kwekhwalithi namazinga e-paclitaxel achazwe ngokuningiliziwe ngezansi.
Ukulawulwa kwekhwalithi ye-paclitaxel
1.ukulawula impahla eluhlaza:izinto ezingavuthiwe ze-paclitaxel kufanele zithengwe kubahlinzeki abaqeqeshiwe.futhi kuqinisekiswe ukuhlanzeka kanye nekhwalithi yezinto ezingavuthiwe.Izinto ezingavuthiwe kufanele zihlolwe ngokuqinile yikhwalithi.okuhlanganisa nokuhlaziywa kwamakhemikhali.ukutholwa kwe-microbial.ukutholwa kokungcola.njll. .ukuqinisekisa ukuthi ziyahlangabezana nezidingo zokukhiqiza.
2.ukulawulwa kwenqubo yokukhiqiza:Enqubweni yokukhiqiza ye-paclitaxel.izinyathelo zokulawula ikhwalithi eziqinile kufanele zithathwe.kuhlanganise nokuqinisekiswa kwenqubo.iphoyinti lokulawula elibalulekile lokuqapha.ukuhlola okuphakathi.etc..ukuqinisekisa ukuzinza kwenqubo yokukhiqiza kanye nokuvumelana komkhiqizo.
3.kuqediwe ukuhlolwa komkhiqizo:paclitaxelimikhiqizo kufanele ibe ukuhlolwa kwekhwalithi okuphelele.okuhlanganisa izici.purity.content.related substances.izinsalela ezincibilikayo nezinye izinto ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo komkhiqizo.
4.ukuhlolwa kokuzinza:imikhiqizo ye-paclitaxel kufanele ibe ukuhlolwa kokuzinza kwesikhathi eside ukuze kuhlolwe izinguquko zekhwalithi ngaphansi kwezimo ezihlukene zesitoreji.ukuhlinzeka ngesisekelo sokufaneleka komkhiqizo.
Izinga le-paclitaxel
1.Ukunqunywa kokuqukethwe:izindlela zokunquma okuqukethwe kwe-paclitaxel ikakhulukazi zifaka ukusebenza okuphezulu kwe-chromatography ye-liquid.i-ultraviolet ebonakalayo i-spectrophotometry nokunye.Kufanele kusungulwe amazinga aqinile okulawula kwangaphakathi ukuze kuqinisekiswe ukuthi okuqukethwe kweqoqo ngalinye lomkhiqizo kuhlangabezana nemithetho.
2.Ukuhlolwa kwezinto ezihlobene:izinto ezihlobene ze-paclitaxel ikakhulukazi zihlanganisa ama-metabolite ayo kanye nemikhiqizo yokubola.Izindlela namazinga okuhlolwa kwezinto ezifanele kufanele asungulwe ukuze kuqinisekiswe ukuthi okuqukethwe kwezinto ezifanele emkhiqizweni ophelile kungaphakathi kwebanga elishiwo.
I-3.solvent residue check:Izincibilikisi ze-Organic zingasetshenziswa enqubweni yokukhiqiza ye-paclitaxel.so umkhiqizo oqediwe kufanele uhlolwe izinsalela ze-solvent ukuze kuqinisekiswe ukuthobela imithetho.
4.ezinye izinto zokuhlola:Ngaphezu kwalezi zinto zokuhlola ezingenhla.ezinye izinto kufanele futhi zihlolwe ngokuvumelana nezimfuneko zekhwalithi yomkhiqizo.njengokusabalalisa usayizi wezinhlayiyana.pH value.moisture.etc.
Isifinyezo
Njengomuthi obalulekile wokulwa nesimila.ukulawulwa kwekhwalithi nezinga lepaclitaxelzibaluleke kakhulu ekuphepheni nasekusebenzeni ngempumelelo komkhiqizo.Izinyathelo zokulawula ikhwalithi eziqinile kufanele zithathwe enqubweni yokukhiqiza ukuze kusungulwe izindinganiso zekhwalithi zesayensi neziphusile ukuze kuqinisekiswe ukuthi izinga leqoqo ngalinye lemikhiqizo lizinzile futhi lithembekile.Ngasikhathi sinye. .ukuqondisa kufanele kuqiniswe ukuze kuqinisekiswe ukuphepha nokuhambisana ngesikhathi sokukhiqiza nokusetshenziswa.Ngokuthuthukiswa okuqhubekayo nokuthuthukiswa kwamazinga okulawula ikhwalithi.ikhwalithi yokukhiqiza kanye nomthelela wokusetshenziswa kwesiguli we-paclitaxel kungathuthukiswa nakakhulu.
Qaphela:Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.
Isikhathi sokuthumela: Nov-16-2023