Veza uhambo oluyinkimbinkimbi lwe-paclitaxel:kusuka ekukhishweni kwemvelo kuye kokwenziwa okungenzeka

I-Paclitaxel iwumkhiqizo wemvelo owakhishwa egxolweni lesihlahla se-Pacific yew(i-Taxus pacifica).I-biosynthesis ye-paclitaxel ihlanganisa izindlela eziyinkimbinkimbi ze-biosynthetic, okuhlanganisa ama-enzyme amaningi kanye nama-intermediates.Nakuba indlela ephelele yokuhlanganiswa kwe-paclitaxel isihloliwe, isekhona inselele ekukhiqizeni kwangempela kwezimboni.Nansi ukubuka kabanzi kwe-paclitaxel biosynthesis:

1.Into yokuqala:I-biosynthesis ye-paclitaxel iqala ngento yokuqala yemvelo, ngokuvamile esuka emaqabunga noma amagxolo esihlahla se-yew.Lezi zinto zokuqala ziqukethe izinhlanganisela zabazali ezingasetshenziswa ukuze kuhlanganiswe izandulela ze-paclitaxel.

2.I-Multi-enzyme catalysis:I-Biosynthesis yepaclitaxelkudinga ama-enzyme amaningi ukuze kuthuthukiswe ukusabela.Lawa ma-enzyme aguqula into eqalayo ibe yizinto eziphakathi nendawo ezihlanganisa kancane kancane ama-molecule andulelayo we-paclitaxel.

I-3.I-Synthesis of Intermediates:I-Intermediates iyisinyathelo esibalulekile ekuhlanganiseni kwe-paclitaxel.Zihlanganisa ama-polycyclic compounds kanye nezakhiwo ze-chain chain ezihlanganiswa kancane kancane ngochungechunge lwe-enzyme-catalyzed reactions.

4.I-Final synthesis ye-paclitaxel:Ama-molecule andulelayo wokuhlanganiswa kwe-paclitaxel kancane kancane ahlanganiswa abe ama-molecule e-paclitaxel ngezinyathelo zokusabela eziningi.Lokhu kusabela kuhlanganisa i-polycyclic synthesis, i-acylation, i-deketone, nezinye izinyathelo ezibalulekile.

5.Ukukhipha kanye nokuhlanzwa:Ngemva kokuhlanganiswa kwe-paclitaxel, isinyathelo sokukhipha kanye nokuhlanza siyadingeka ukuze kuhlukaniswe i-paclitaxel ehlanzekile nengxube yokusabela.

Nakuba izindlela zemvelo ze-biosynthetic zepaclitaxelKuye kwacutshungulwa, ukukhiqizwa kwangempela kwe-paclitaxel kuhlala kuyinselele ngoba kudinga ukuhlanganiswa okuyinkimbinkimbi nezinyathelo eziningi kanye nenani elikhulu lezinto zokusetshenziswa.Ngenxa yalezi zinselele, ososayensi baye baphenya izindlela zokwenziwa ukuze kuhlanganiswe i-paclitaxel ukuze kwandiswe isivuno sayo nokutholakala kwayo.I-Synthetic i-synthesis ye-paclitaxel ngokuvamile ihilela umzila wokuhlanganisa owenziwe lula ukuze kuncishiswe ubunkimbinkimbi.

Qaphela:Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.

I-Yunnan Hande Biotechnology Co., Ltd. ibigxile ekukhiqizweni kwe-paclitaxel iminyaka engama-26, futhi ingumkhiqizi ozimele we-anti-cancer drug paclitaxel API ekhishwe esitshalweni egunyazwe yi-United States FDA,European EDQM,Australia TGA,China CFDA. ,India,Japan kanye nezinye izinhlaka zokulawula zikazwelonke.Yunnan Hande paclitaxel,spot supply,factory direct sales,Siyakwamukela ukubuza,18187887160(WhatsApp inombolo efanayo)