Ucwaningo ngomphumela wokwelapha we-paclitaxel ezinhlotsheni ezahlukene zomdlavuza

I-Paclitaxel iyinhlanganisela yemvelo ekhishwe esitshalweni se-yew, esinomsebenzi obalulekile wokulwa nesimila. Njengoba i-paclitaxel yaqala ukuhlukaniswa namagxolo e-Pacific yew ngo-1971, ucwaningo lwayo emkhakheni wokwelapha umdlavuza lube nesithakazelo esikhulu. hlola ngokujulile imiphumela yokwelapha yepaclitaxelezinhlotsheni ezahlukene zomdlavuza.

Isakhiwo kanye nezakhiwo ze-paclitaxel

I-Paclitaxel iyinhlanganisela eyinkimbinkimbi ye-tetracyclic diterpenoid enesakhiwo esiyingqayizivele esinezinhlangothi ezintathu, esihlinzeka ngesisekelo somsebenzi wayo wokulwa nesimila.

Indlela yokulwa nomdlavuza yepaclitaxel

I-anti-cancer mechanism ye-paclitaxel ihlobene ngokuyinhloko nokuvinjelwa kwayo kwe-tubulin depolymerization kanye nomthelela wayo ekuhlukaniseni amaseli nokwanda. Ngaphezu kwalokho, i-paclitaxel ingase futhi ibangele i-apoptosis yeseli futhi ivimbele i-angiogenesis yesimila.

Umphumela wokwelapha we-paclitaxel ezinhlotsheni ezahlukene zomdlavuza

1.Umdlavuza Webele:Umphumela wokwelapha we-paclitaxel kumdlavuza webele usuqashelwe kabanzi.Ocwaningweni olwenziwa ezigulini ezinomdlavuza webele webele, i-paclitaxel ehlanganiswe nokwelashwa ngamakhemikhali kuholele ekuncipheni kwesimila ezigulini ezingama-41% kanye nokusinda okuyizinyanga ezingaphezu kwezingama-20.

2.Umdlavuza wamaphaphu wamangqamuzana ongewona omncane:Kumdlavuza wamaphaphu ongewona omncane, i-paclitaxel ehlanganiswe nemithi ye-chemotherapy esekelwe ku-platinum ingathuthukisa kakhulu ukusinda kweziguli.Ucwaningo lweziguli ezingu-36 ezinomdlavuza wamaphaphu ongewona omncane lubonise ukuthi i-paclitaxel ihlangene ukwelashwa ngamakhemikhali kubangele ukusinda okumaphakathi kwezinyanga eziyi-12.

3. Umdlavuza wesibeletho: Ekwelapheni iziguli zomdlavuza we-ovarian ezingama-70, i-paclitaxel ehlanganiswe nemithi ye-chemotherapy esekwe ku-platinum inciphise izimila ku-76% weziguli, futhi izinga lokusinda leminyaka emibili lafinyelela ku-38%.

4.Umdlavuza womminzo:Ekwelapheni iziguli ezingu-40 ezinomdlavuza womminzo, i-paclitaxel ehlanganiswe ne-radiotherapy inciphise izimila ku-85% weziguli, futhi izinga lokusinda lonyaka owodwa lifinyelele ku-70%.

5.Umdlavuza wesisu:Ekwelapheni umdlavuza wesisu, i-paclitaxel ehlanganiswe ne-fluorouracil ingathuthukisa kakhulu ukusinda kweziguli.Ocwaningweni lweziguli ezingama-50 ezinomdlavuza wesisu,paclitaxelkuhlanganiswe nokwelashwa ngamakhemikhali kubangele ukusinda okumaphakathi kwezinyanga eziyi-15.

6.Umdlavuza Wamabala: Ekwelapheni iziguli ezingama-30 ezinomdlavuza we-colorectal, i-paclitaxel ehlanganiswe ne-oxaliplatin inciphise izimila ku-80% weziguli, futhi izinga lokusinda leminyaka emibili lafinyelela ku-40%.

7.Umdlavuza Wesibindi: Yize umphumela we-paclitaxel monotherapy kumdlavuza wesibindi unomkhawulo, inhlanganisela yezinye izidakamizwa ze-chemotherapy njenge-cisplatin ne-5-fluorouracil ingathuthukisa kakhulu ukusinda kweziguli. Ucwaningo lweziguli ezingu-40 ezinomdlavuza wesibindi lubonise ukuthi i-paclitaxel ihlangene. nge-chemotherapy kuholele ekusindeni okumaphakathi kwezinyanga eziyi-9.

8.Umdlavuza wezinso: Ekwelapheni umdlavuza wezinso, i-paclitaxel ehlanganiswe nemithi evimbela ukuzivikela komzimba njenge-interferon-alpha ingathuthukisa kakhulu ukusinda kweziguli. Ucwaningo lweziguli ezingu-50 ezinomdlavuza wezinso lubonise ukuthi i-paclitaxel ehlanganiswe nokwelashwa komzimba kwaholela ekusindeni okuphakathi. Izinyanga ezingama-24.

9.I-Leukemia:Ekwelapheni i-acute myeloid leukemia, i-paclitaxel ehlanganiswe nemithi yokwelapha ngamakhemikhali njenge-cytarabine ingenza iziguli zithole izinga eliphezulu lokuphulukiswa okuphelele. ezigulini ezingama-80%.

10, i-lymphoma:Ekwelapheni i-non-Hodgkin lymphoma, i-paclitaxel ehlanganiswe nemithi yokwelapha ngamakhemikhali njenge-cyclophosphamide ingenza iziguli zithole isilinganiso esiphezulu sokusabela. impendulo ephelele kuma-85% eziguli.

Isiphetho

Kafushane, i-paclitaxel ibonise ukusebenza kahle okuthile ekwelapheni izinhlobo ezahlukene zomdlavuza.Nokho, kubalulekile ukuqaphela ukuthi ukusebenza kahle kokwelashwa kuyehluka ngohlobo ngalunye lomdlavuza futhi kuvame ukudingeka lapho kuhlanganiswe nezinye izidakamizwa.Ngaphezu kwalokho, ngenxa ubunkimbinkimbi kanye nokwehluka komuntu ngamunye komdlavuza, izinhlelo zokwelapha kufanele zenziwe ngesiguli ngasinye.Izifundo zesikhathi esizayo kufanele zihlole amandla e-paclitaxel ekwelapheni umdlavuza futhi zandise ukusetshenziswa kwayo.

Qaphela:Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.