Izidakamizwa ze-Paclitaxel zithathwe njengokwelashwa kokuqala komdlavuza webele, futhi zisetshenziswa kabanzi emtholampilo umdlavuza wesibeletho, umdlavuza wamaphaphu, izimila zekhanda nentamo, umdlavuza womminzo, umdlavuza wesisu kanye ne-sarcoma yezicubu ezithambile.Eminyakeni yamuva nje, ngokuhlolwa okuqhubekayo kwezidakamizwa ze-paclitaxel kanye nokwenza ngcono okuqhubekayo kwenqubo yokwakheka, le mithi manje ikakhulukazi ihlanganisa umjovo we-paclitaxel, i-docetaxel (i-docetaxel), i-liposomal paclitaxel ne-albumin-bound paclitaxel.Ngakho-ke yimuphi umehluko phakathi kwalezi zidakamizwa ze-paclitaxel, ake sifunde kabanzi ngazo ngezansi.
I. Umehluko emisebenzini eyisisekelo
1. Umjovo we-Paclitaxel: Uboniswa ukwelashwa komugqa wokuqala nokulandelwayo komdlavuza wesibeletho oqhubekayo, ukwelashwa kwe-adjuvant yomdlavuza webele we-lymph node-positive ngemva kohlobo olujwayelekile lwe-adriamycin-containing combination chemotherapy, umdlavuza webele kumdlavuza webele we-metastatic. wehlulekile ukwelashwa ngamakhemikhali okuhlanganisiwe noma waphinde wabuyela emuva phakathi nezinyanga ezingu-6 zokwelashwa ngamakhemikhali, ukwelashwa kokuqala komdlavuza wamaphaphu wamangqamuzana ongewona omncane, kanye nokwelashwa komugqa wesibili we-carcinosarcoma ehambisana nesiguli se-AIDS.
2. I-Docetaxel: Ekwelapheni umdlavuza webele osethuthukile noma ometastatic owehluleke ngaphambi kokwelashwa ngamakhemikhali;yokwelashwa komdlavuza wamaphaphu osezingeni eliphezulu noma we-metastatic ongewona omncane ohlulekile nge-cisplatin-based chemotherapy.Iyasebenza futhi kumdlavuza wesisu kanye nomdlavuza wendlala yesinye.
3. I-Liposomal paclitaxel: Ingasetshenziswa njengendlela yokuqala yokwelapha ngamakhemikhali yomdlavuza wesibeletho kanye nokwelashwa ngamakhemikhali komugqa wokuqala ekwelapheni umdlavuza we-ovarian metastatic, futhi ingasetshenziswa futhi kuhlanganiswe ne-cisplatin.Ingase futhi isetshenziselwe ukwelashwa okulandelwayo kweziguli ezinomdlavuza webele ezibelashwe nge-chemotherapy evamile equkethe i-adriamycin noma ekwelapheni iziguli eziphindelelayo.Ingasetshenziswa futhi kuhlanganiswe ne-cisplatin njengokwelashwa ngamakhemikhali komugqa wokuqala ezigulini ezinomdlavuza wamaphaphu wengqamuzana ongewona omncane ezingakwazi ukwelapha ngokuhlinzwa noma nge-radiotherapy.
4. I-Albumin-bound paclitaxel: ekhonjiswe ekwelapheni umdlavuza webele we-metastatic owehlulekile ukwelashwa ngamakhemikhali okuhlanganisiwe noma umdlavuza webele ophinde wavela phakathi nezinyanga ezingu-6 ngemva kokwelashwa ngamakhemikhali kwe-adjuvant.Ngaphandle uma kukhona ukungqubuzana komtholampilo, ukwelashwa ngamakhemikhali kwangaphambilini kufanele kufake i-anthracycline ejenti yokulwa nomdlavuza.
II.Umehluko ekuphepheni kwezidakamizwa
1. I-Paclitaxel: ukungancibiliki kahle kwamanzi.Ngokuvamile, umjovo uzofaka amafutha e-castor esikhundleni se-polyoxyethylene esikhundleni sawo kanye ne-ethanol ukuze kuthuthukiswe ukunyibilika kwe-paclitaxel emanzini, kodwa i-histamine ikhishwa lapho uwoyela we-castor ofakwe esikhundleni se-polyoxyethylene wonakaliswa ku-vivo, okungaholela ekungezwani komzimba okubi kakhulu futhi kungase kubhebhethekise. i-peripheral neurotoxicity ye-paclitaxel, futhi ingathinta nokusatshalaliswa kwama-molecule ezidakamizwa ezicutshini futhi ithinte umphumela wokulwa nesimila.
2. I-Docetaxel: ukuncibilika kwamanzi kuphansi, futhi kudinga ukuncibilika ngokungeza i-polysorbate 80 ne-anhydrous ethanol, kokubili okungase kwenyuse ukuvela kokusabela okubi futhi kungabangela ukungezwani komzimba ne-hemolytic.
3. I-Liposomal paclitaxel: isidakamizwa sifakwe kuma-bilayers afana ne-lipid ukuze senze ama-vesicles amancane, futhi umuthi ufakwe ezinhlayiyeni ze-liposomal ngaphandle kwe-polyoxyethylene-substituted oil castor kanye ne-anhydrous ethanol, okubangela ukungezwani komzimba.Kodwa-ke, ucwaningo luye lwabonisa ukuthi umuthi we-paclitaxel ngokwawo ungadala ukusabela kwe-hypersensitivity, kodwa ngenani eliphansi uma uqhathaniswa nomjovo we-paclitaxel.Njengamanje, i-paclitaxel liposomes isadinga ukwelashwa kwangaphambili kokungezwani komzimba ngaphambi kokusetshenziswa.
4. I-albumin-bound paclitaxel: I-albumin entsha ye-albumin e-lyophilized esebenzisa i-albumin yomuntu njengomthwali wezidakamizwa nezinzisi, enganawo amafutha e-castor afakwe esikhundleni se-polyoxyethylene futhi anokuqukethwe okuphansi kwe-paclitaxel okunama-paclitaxel liposomes, futhi ayinawo. zidinga ukwelashwa ngaphambi kokwelashwa.
Qaphela: Ukusebenza okungaba khona kanye nezicelo ezivezwe kulesi sethulo kuthathwe ezincwadini ezishicilelwe.
I-Yunnan Hande Biotechnology Co., Ltd ibisebenza ngokukhethekile ekukhiqizenipaclitaxel APIiminyaka engaphezu kwengu-20, futhi ingomunye wabakhiqizi abazimele bomhlaba be-paclitaxel API, umuthi wokulwa nomdlavuza osuselwe esitshalweni, ogunyazwe yi-US FDA, i-European EDQM, i-Australian TGA, i-CFDA yamaShayina, i-India, i-Japan nezinye izinhlangano ezilawula izwe. .I-Hande ayikwazi ukunikeza izinga eliphezulu kuphelapaclitaxel izinto zokusetshenziswa, kodwa futhi nezinsizakalo zokuthuthukiswa kobuchwepheshe ezihlobene nokwakhiwa kwe-paclitaxel.Ukuze uthole olunye ulwazi, sicela ukhululeke ukusithinta ku-18187887160.
Isikhathi sokuthumela: Dec-08-2022