Ukulala kuyingxenye ebalulekile yokuphila komuntu kwansuku zonke, okunomthelela obalulekile empilweni yomuntu engokomzimba nengqondo, ukusebenza komzimba nokusebenza kwengqondo.I-Melatonin, i-hormone ekhishwa indlala ye-pineal, idlala indima ebalulekile ekulawuleni isigqi sokulala nokugcina isimo sokulala.Lesi sihloko sizobuyekeza umphumela olawulayo we-melatonin ekulaleni ngokombono wezincwadi zochwepheshe.
Isakhiwo kanye nesimiso somfihlo se-melatonin
I-Melatonin iwuhlobo lwehomoni ye-indole ehlanganiswe futhi yakhishwa indlala ye-pituitary ye-mammalian pineal gland, enesigqi esisobala.Endaweni enokukhanya okwanele, i-retina izwa ukukhanya futhi ivimbele ukwakheka kwe-melatonin nokuphuma nge-retina-hypothalamic-pineal axis.Endaweni emnyama, i-retina ayizizwa ilula, futhi ikhuthaza ukuhlanganiswa nokuphuma kwe-melatonin ngokusebenzisa i-retina-hypothalamic-pineal axis.
Umthelela we-melatonin kukhwalithi yokulala
I-Melatoninikhuthaza ukulala ngokuyinhloko ngokusebenzisana nama-melatonin receptors athile ukulawula iwashi le-circadian futhi ivimbele ukuphaphama.Ebusuku, amazinga e-melatonin ayakhuphuka, okusiza ukulungisa iwashi lebhayoloji yomzimba futhi ilethe umuntu ukuba alale.Ngesikhathi esifanayo, i-melatonin ingasiza futhi ukugcina ubuthongo ngokucindezela ukuphaphama.Ucwaningo luye lwabonisa ukuthi umphumela wokulawula we-melatonin ekulaleni uhlobene eduze nomthamo kanye nesikhathi sokuphatha.
Okwesithathu, ukuphazamiseka kwe-melatonin kanye nezifo ezihlobene nokulala
Ukungasebenzi kahle kwe-melatonin kungaholela ekuphazamisekeni kokulala nezinye izinkinga ezihambisana nokulala.Isibonelo, ukuphazamiseka kokulala okufana nokuqwasha, i-shift syndrome, nobunzima bokujwayela i-jet lag kuhlobene nokuphazamiseka kwesigqi se-melatonin secretion.Ngaphezu kwalokho, olunye ucwaningo luye lwabonisa ukuthi ukukhiqizwa kwe-melatonin okwanele kungase kwandise ingozi yesifo i-Alzheimer's, ukucindezeleka nezinye izifo.
isiphetho
Indima ye-melatonin ekulawuleni ukulala iye yacwaningwa kabanzi emazingeni amaningi.Kodwa-ke, naphezu kwendima esungulwe kahle ye-melatonin ekulawuleni ukulala, kusenemibuzo eminingi okusamele iqhutshekwe ihlolwe.Isibonelo, indlela ethile yokusebenza ye-melatonin isadinga ukuqhutshekiselwa phambili ukufunda;Umthelela we-melatonin ekulawulweni kokulala ungase uhluke kubantu abahlukene (njengabantu abaneminyaka ehlukene, ubulili kanye nemikhuba yokuphila).Futhi hlola ukusebenzisana phakathi kwe-melatonin nezinye izici zempilo yengqondo nengokwengqondo.
Ngaphezu kwalokho, kufanele kuphawulwe ukuthi nakuba ukusetshenziswa kwe-melatonin ekulawuleni ubuthongo kukhombisa amathemba athembisayo, ukuphepha kwayo, ukusebenza kahle nokusetshenziswa kwayo kahle kusadinga ubufakazi obengeziwe bomtholampilo.Ngakho-ke, izikhombisi-ndlela zocwaningo lwesikhathi esizayo kufanele zibandakanye ukwenza izivivinyo zomtholampilo ezengeziwe ukuze kuqinisekiswe umphumela wangempela we-melatonin ekuthuthukiseni ukulala nokuphazamiseka okuhlobene.
ireferensi
I-Bachman,JG,&Pandi-Perumal,SR(2012).I-Melatonin:izicelo zomtholampilo ezingaphezu kokuphazamiseka kokulala.Journal of pineal research,52(1),1-10.
Brayne,C.,&Smythe,J.(2005).Indima ye-melatonin ebuthongweni kanye nokubaluleka kwayo emtholampilo.Journal of Pineal Research,39(3),
Isikhathi sokuthumela: Sep-27-2023