Indima ye-10-Dab Semi-Synthetic Paclitaxel

I-Paclitaxel, njengesidakamizwa sokuqala se-chemotherapy esikhishwe ezitshalweni zemvelo, isengomunye wezidakamizwa ezivamile ku-chemotherapy chemotherapy kuze kube namuhla.I-Paclitaxelumuthi wemvelo wokulwa nesimila okhishwe ezitshalweni ze- taxus, futhi indlela yawo yokusebenza ukukhuthaza ukuhlangana kwe-microtubule ukuvimbela i-tumor cell mitosis.Ingenye yezidakamizwa zemvelo ezingcono kakhulu zokulwa nesimila emakethe yezemithi, futhi kunesidingo esikhulu. emakethe yezemithi yamazwe ngamazwe.I-Paclitaxel ihlukaniswe nge-paclitaxel yemvelo kanye ne-semi synthetic paclitaxel.Ake sibheke indima ye-10-Dab Semi-Synthetic Paclitaxel embhalweni olandelayo.

I-10-Dab Semi-Synthetic Paclitaxeli-semi synthetic paclitaxel derivative enemisebenzi yemithi efana ne-paclitaxel yemvelo.I-Paclitaxe iyisidakamizwa esiphumelelayo sokulwa nomdlavuza, esingasetshenziswa ukwelapha izinhlobo ezihlukahlukene zomdlavuza, njengomdlavuza webele, umdlavuza wesibeletho, umdlavuza wamaphaphu nomdlavuza wesisu. ye-precursor 10-DAB ye-paclitaxel ngokusebenzisa izindlela ze-semi synthetic ingakhuphula isivuno nobumsulwa be-paclitaxel, yehlise izindleko zokukhiqiza, futhi yenze i-paclitaxel isimeme futhi yonge. kumaseli athile esimila.

I-10-Dab Semi-Synthetic Paclitaxelingasebenzisa imisebenzi eminingi kanye nemiphumela, hhayi nje njengomkhiqizo omaphakathi womuthi, kodwa futhi njengomkhiqizo wempahla eluhlaza yomuthi.Ngokubukeka kwayo, ibonakala njengekristalu emhlophe.Isetshenziswa kakhulu embonini yezemithi futhi ingaba esetshenziswa njengezinto ezingavuthiwe emithini, enomthelela omuhle kakhulu ekukhiqizeni imishanguzo elwa namagciwane ebanzi.