I-Paclitaxel, umkhiqizo wemvelo okhishwe ku-fir ebomvu, ivimbela i-tumor cell mitosis ngokusebenza kumaprotheni e-microtubule.Ingummeleli ojwayelekile wesigaba se-paclitaxel futhi iwumuthi wokuqala wamakhemikhali ovela esitshalweni semvelo ukuthola imvume ye-FDA yokwelapha izinhlobo zomdlavuza, okuhlanganisa umdlavuza wesibeletho, webele, wamaphaphu, i-Kaposi's sarcoma, umdlavuza womlomo wesibeletho kanye nomdlavuza wamaphaphu.Eminyakeni yakamuva,paclitaxeliye yazuza nokuduma ngokusetshenziswa kwayo emishinini yezokwelapha.Ake sikubheke esihlokweni esilandelayo.
Ukusetshenziswa kwepaclitaxelemishinini yezokwelapha
I-Paclitaxel, ngokusebenzisa i-polymerization ngesikhathi esisodwa ne-α (α-tubulin) kanye ne-β (β-tubulin) ye-microtubulin, ibangela inani elikhulu lama-microtubules ukuba enze i-polymerize ngendlela engavamile, okuholela ekuguqulweni kwesimo sokulinganisa kwamathambo kanye nokulahlekelwa umsebenzi ojwayelekile, okwenza ukuthuthukiswa kwamaseli kume esigabeni se-G0/G1 kanye nesigaba se-G1 kanye ne-GM, futhi i-cell mitosis ivinjelwe esigabeni se-mitotic, ekugcineni ifinyelele ukuvinjelwa kwe-vascular smooth muscle division, ukwanda Umphumela uwukuvimbela ukuhlukana nokwanda kwe-vascular smooth muscle. futhi uvimbele i-restenosis ukuthi ingenzeki.
1. I-Paclitaxeli-stent yezidakamizwa
I-Drug-eluting stent (DES) iyi-stent esebenzisa isiteji sensimbi engenalutho ukuze ithwale (iphathe) isidakamizwa esilwa nokwanda kwe-endothelial, esikhishwa i-lution yendawo emkhunjini ukuze kuvimbele ngempumelelo ukwanda kwe-endothelial ukuze kuvinjwe i-restenosis i-stent.Ukusetshenziswa okuphumelelayo kwezidakamizwa-eluting stents kunciphisa kakhulu isigameko sokuphumula nokungenelela kabusha, kodwa akuzange kunciphise izinga lokugula nokufa.Kwakungekho mehluko omkhulu ezenzakalweni zezehlakalo zokuphela komtholampilo phakathi kwama-stents e-eluting drug, kanti amanye amaphuzu esibili azuzayo.Ama-stents akhipha izidakamizwa ahlanganisa ama-stents angenalutho enziwe ngensimbi engagqwali noma i-cobalt-chromium embozwe ngabathwali bezidakamizwa ezivimbela ukukhiqizwa kwezidakamizwa ezinezimbotshana zokulethwa kwezidakamizwa ze-polymeric okuhlanganisa ubuchwepheshe bokunamathela obungapheli, obubolayo, nobungena-polymer, futhi aqukethe izidakamizwa ezihlanganisa i-limoxylates ne-paclitaxel.Njengamanje, ama-stents ezidakamizwa ze-paclitaxel asetshenziswa kakhulu ekwelapheni izifo ezahlukahlukene ze-coronary, intracranial, carotid, renal and femoral arteries.
2. Amabhaluni e-Paclitaxel ambozwe ngezidakamizwa
Ibhaluni elihlanganiswe nezidakamizwa (i-DCB), njengendlela yokungenelela entsha nevuthiwe, ifakazelwe ezivivinyweni ezimbalwa zomtholampilo ngokusebenza kwayo nokuphepha ku-ISR, izilonda ze-intracoronary stenosis, izilonda zemikhumbi emincane, izilonda ze-bifurcation, njll.
Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezichazwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.
Ukufunda okunwetshiwe:I-Yunnan Hande Biotechnology Co., Ltd. ibigxile ekukhiqizweni kwe-paclitaxel iminyaka engama-28.Ingumkhiqizi wokuqala ozimele emhlabeni womuthi we-anticancer osuselwa esitshalweni ugunyazwe yi-US FDA, European EDQM, Australian TGA, China CFDA, India, Japan kanye nezinye izikhungo zokulawula zikazwelonke.ibhizinisi.Uma ufuna ukuthengaI-Paclitaxel API, sicela usithinte ku-inthanethi.
Isikhathi sokuthumela: Oct-09-2022