Yiziphi izinzuzo ze-paclitaxel polymer micelles?

Siyazi ukuthi izinhlobo ze-paclitaxel ezikhangisiwe zifaka umjovo we-paclitaxel, i-liposomal paclitaxel, i-docetaxel, ne-albumin-bound paclitaxel.Yiziphi izinzuzo ze-paclitaxel esanda kuthengiswa kanye ne-paclitaxel polymer micelles?Ake sibheke okulandelayo.

Izinzuzo ze-paclitaxel polymer micelles

1. I-copolymer iyazihlanganisa ngokwayo emanzini ukuze yakhe i-nanocarrier enesakhiwo se-"core-shell".I-nuclear encapsulated paclitaxel ye-micelle ayonakaliswanga, ukuze idlale indima egazini isikhathi eside.

2. Izinhlayiya ze-polymer micellar paclitaxel zincane kakhulu (18-20nm), ezingase ziqondiswe kancane endaweni ezungezile yesimila enokuphazamiseka kwemithambo.Ngale ndlela, umuthi kungenzeka ukuthi uhlale esicutsheni sesimila, okuholela ekugxilweni kwawo okuphezulu ezicutshini zesimila kanye nokugxila okuphansi kwezicubu ezijwayelekile.Ngenkathi kuthuthukisa ukusebenza kahle, izehlakalo zemiphumela emibi ziyancipha ngokwengeziwe.

Ukusetshenziswa kwe-paclitaxel polymer micelles e-china

Ngo-Okthoba 2021, i-China National Drug Administration (NMPA) yamemezela ukuthi i-paclitaxel polymer micelle yokuqala e-China isigunyaziwe, futhi inkomba kwakungumdlavuza wamaphaphu ongewona omncane.

Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezethulwe kulesi sihloko konke kuvela ezincwadini ezishicilelwe.

I-Yunnan Hande Biotechnology Co., Ltd ibisebenza ngokukhethekile ekukhiqizenipaclitaxel APIiminyaka engaphezu kwengu-20, futhi ingomunye wabakhiqizi abazimele bomhlaba be-paclitaxel API, umuthi wokulwa nomdlavuza osuselwe esitshalweni, ogunyazwe yi-US FDA, i-European EDQM, i-Australian TGA, i-CFDA yamaShayina, i-India, i-Japan nezinye izinhlangano ezilawula izwe. .I-Hande ayikwazi ukunikeza izinga eliphezulu kuphelapaclitaxel izinto zokusetshenziswa, kodwa futhi nezinsizakalo zokuthuthukiswa kobuchwepheshe ezihlobene nokwakhiwa kwe-paclitaxel.Ukuze uthole olunye ulwazi, sicela ukhululeke ukusithinta ku-18187887160.