Iyini i-albumin-bound paclitaxel?

Iyini i-albumin-bound paclitaxel?I-Albumin-bound paclitaxel (evame ukubizwa ngokuthi i-albumin paclitaxel, efushaniswa nangokuthi i-Nab-P) iyi-paclitaxel nanoformulation entsha, eyaziwa emhlabeni wonke njengokwakheka okuthuthuke kakhulu kwe-paclitaxel.Ihlanganisa i-albumin yomuntu engapheli ne-paclitaxel ngendlela engahlangani futhi ama-nanoparticles angumphumela anqoba ngokuphelele ukonakala kwe-paclitaxel ukungancibiliki emanzini, ngaphandle kwesidingo samafutha e-polyoxyethylene castor noma i-Tween 80 njengesixazululi esihlangene.Njengoba i-albumin ingumkhiqizo wemvelo ongapheli, inezinzuzo zokuthi iphephile, ingenabuthi, ingenawo amasosha omzimba, i-biodegradable, kanye ne-biocompatible.

Kungani i-albumin-bound paclitaxel ithuthuke kakhulu?

1. Akukho co-solubilizationno pre-treatment

Ukwamukela iphrotheni ye-plasma yemvelaphi yemvelo, ibopha ama-molecule e-hydrophobic paclitaxel ngendlela engeyona i-covalent ngaphandle kwanoma iyiphi i-co-solvent, iqede ukusabela kwe-hypersensitivity kanye nobuthi obubangelwa ama-co-solvents, ngaleyo ndlela iqede isidingo sokwelashwa kwangaphambili kwe-hormone ngaphambi kokusetshenziswa nokunciphisa isikhathi sokumnika. kuze kube yimizuzu engama-30, kufinyeze kakhulu ukuhlala esibhedlela kweziguli ze-oncology, ngisho nokuqeda ukwelashwa ngamakhemikhali ngomtholampilo wansuku zonke.

2. I-pharmacokinetics engcono

Uma kuqhathaniswa ne-paclitaxel evamile, i-albumin paclitaxel inokusabalalisa kwezicubu ezisheshayo neziphakeme emzimbeni, kanye nokuphuma kancane kancane kwezicubu, umthamo obekezeleleke emzimbeni womuntu ungakhuphuka kakhulu futhi umphumela wokwelapha uthuthukiswa kakhulu.

3. Ukuhlanganiswa kwesimila sendawo esikhethiwe

Esinye sezizathu ezenza iziguli eziningi zesabe i-paclitaxel chemotherapy ukuthi ukusatshalaliswa kwe-paclitaxel yendabuko ezicutshini zesimila nezinye izicubu ezijwayelekile kuyafana ngokuyisisekelo, okubangela imiphumela emibi eminingi.Ngokuphambene, i-paclitaxel “inothile ngokukhetha isimila sendawo” ngokuyisimangaliso futhi ukugxila kwayo ezicutshini zesimila kuphakeme kakhulu kunakwezinye izicubu ezivamile.

Qaphela: Imiphumela engaba khona kanye nezinhlelo zokusebenza ezichazwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.

I-Yunnan Hande Bio-Tech Co., Ltd ibisebenza ngokukhethekile ekukhiqizenipaclitaxel APIiminyaka engaphezu kwengu-20, futhi ingomunye wabakhiqizi abahamba phambili emhlabeni be-paclitaxel API ngemvume ye-FDA, isitifiketi se-CEP nesitifiketi se-GMP e-China.I-Hande ayikwazi ukunikeza kuphela i-paclitaxel API yekhwalithi ephezulu kodwa futhiisevisi yokudlulisa ubuchwepheshe ye-paclitaxel albumin.Ukuze uthole olunye ulwazi, sicela ukhululeke ukusithinta ku-18187887160.