Uyini umehluko phakathi kwezinhlobo ezine ze-“paclitaxel”?

I-Paclitaxel, eyaziwa nangokuthi i-red paclitaxel, i-tamsulosin, i-violet, ne-tesu, iyisidakamizwa semvelo esingcono kakhulu sokulwa nomdlavuza esatholakala kuze kube manje, futhi isetshenziswe kabanzi ekwelapheni umdlavuza webele, umdlavuza wesibeletho, kanye nomdlavuza wekhanda nentamo kanye umdlavuza wamaphaphu.Njengomuthi wakudala we-chemotherapy, igama likapaclitaxelkukholakala ukuthi abantu abaningi sebezwile ngakho.Ake sibheke umehluko phakathi kwezinhlobo ezine ze-paclitaxel esihlokweni esilandelayo.

Umehluko phakathi kwezinhlobo ezine zepaclitaxel

I-1, i-Paclitaxel: Isebenza ohlelweni lwe-microtubule/microtubule protein, ivimbela i-microtubule depolymerization, ivimba umjikelezo weseli esigabeni se-G2/M, iholele ku-mitosis engavamile noma ukuboshwa, ivimbele ukuphindaphinda kweseli yesimila, futhi yenza amangqamuzana omdlavuza angakwazi ukuqhubeka nokuhlukana nokufa.

I-2, i-Docetaxel: Indlela yokusebenza iyafana naleyo ye-paclitaxel, kodwa ngokusondelana okuphezulu nendawo yokubopha i-microtubule kanye nomsebenzi ophezulu wokulwa nomdlavuza.

3, I-Liposomal paclitaxel:Indlela yokusebenza iyafana neye-paclitaxel.Ama-liposomes akhiwe i-lecithin, cholesterol, i-threonine nezinye izinto ezifana nesakhiwo se-phospholipid bilayer se-cell membranes encapsulate paclitaxel, engathuthukisa ukunyibilika kwamanzi, ingene kalula. kuzicubu zesimila ezivela emithanjeni yegazi, futhi kunciphise ubuthi benhliziyo nezinso, njll.

4.I-albumin-bound paclitaxel:i-hydrophobic paclitaxel ihlanganiswa ne-serum albumin carrier nge-nanotechnology.I-Albumin ingakhuphula ukumuncwa kwe-paclitaxel esimila ngokubopha i-gp60 receptor futhi ikhulise ukugcwala kwe-paclitaxel esicutshini sesimila, ngaleyo ndlela ikhulise umphumela wokulwa nesimila. .

Kokubili i-paclitaxel, i-doxorubicin, i-paclitaxel liposome noma i-albumin paclitaxel iwuhlobo olufanayo lwezidakamizwa ze-chemotherapeutic, futhi zonke ziyingxenye ye-paclitaxel esigabeni semithi yokwelapha i-chemotherapeutic. inhibitor, esetshenziswa kabanzi ekwelapheni umdlavuza webele.

Qaphela: Ukusebenza okungaba khona kanye nezicelo ezihlanganiswe kule phrezentheshini kuthathwe ezincwadini ezishicilelwe.

Ukufunda okunwetshiwe:I-Yunnan Hande Biotechnology Co., Ltd. ibigxile ekukhiqizweni kwe-paclitaxel iminyaka engama-28.Ingumkhiqizi wokuqala ozimele emhlabeni womuthi we-anticancer osuselwa esitshalweni ugunyazwe yi-US FDA, European EDQM, Australian TGA, China CFDA, India, Japan kanye nezinye izikhungo zokulawula zikazwelonke.ibhizinisi.Uma ufuna ukuthengaI-Paclitaxel API, sicela usithinte ku-inthanethi.