I-Glabridin isuka esitshalweni i-Glycyrrhiza glabra, ikhona kuphela empandeni nesiqu se-Glycyrrhiza glabra(Eurasia), futhi iyisakhi esiyinhloko se-Isoflavone ye-Glycyrrhiza glabra.I-Glabridininokumhlophe, i-antioxidant, anti-inflammatory kanye neminye imiphumela.Ngenxa yokuqukethwe okuphansi kwe-glabridin kanye nobunzima benqubo yokuhlanza, inesihloko esithi"igolide elimhlophe".
1, Umgomo wokuba mhlophe we-Glabridin
Ngaphambi kokuqonda isimiso sokwenza mhlophe kwe-glabridin, kudingeka siqale siqonde kafushane izimbangela zokukhiqizwa kwe-melanin.
Ukwakhiwa kwe-melanin kudinga izinto ezintathu eziyisisekelo:
I-Tyrosine: Impahla eluhlaza eyinhloko yokukhiqiza i-melanin.
I-Tyrosinase: i-enzyme enciphisa isilinganiso esikhulu eguqula i-tyrosine ibe yi-melanin.
Izinhlobo zomoya-mpilo osebenzayo:I-Tyrosine kufanele ihlanganiswe nomoya-mpilo ohlelweni lokukhiqiza i-melanin ngaphansi kwesenzo se-Tyrosinase.
I-Tyrosinase ingakhiqiza i-melanin njalo.Izisusa zangaphandle (kuhlanganise nemisebe ye-ultraviolet evamile, ukuvuvukala, ukungezwani komzimba nezinto ezithile, njll.) zingaholela ekukhipheni ngokweqile, okuholela ekubeni mnyama.
Ngasikhathi sinye, izinhlobo ze-oxygen esebenzayo (i-ROS) ezibangelwa imisebe ye-ultraviolet zingalimaza ulwelwesi lwe-phospholipid lwezicubu zesikhumba, olubonakala njenge-erythema kanye ne-pigmentation esikhumbeni. Ngakho-ke, i-ROS iyinto engabangela umbala esikhumbeni. isizukulwane sawo singavimbela ukukhiqizwa kwe-melanin kanye ne-pigmentation.
2, Izinzuzo ezimhlophe ze-Glabridin
Ngamafuphi, inqubo yokwenza mhlophe kanye nokukhanya kwamabala kuyinqubo yokulwa ne-Tyrosinase kanye nezinhlobo zomoya-mpilo osebenzayo.
I-Glabridin ivimbela ikakhulukazi umsebenzi we-Tyrosinase ngokuvinjelwa kocansi kokuncintisana, isusa ingxenye ye-Tyrosinase kude neringi ye-melanin synthesis, ivimbela ukuhlanganiswa kwe-substrate ne-Tyrosinase, ngaleyo ndlela ivimbele ukuhlanganiswa kwe-melanin.Ngasikhathi sinye,i-glabridinngokwayo inemiphumela emihle ye-antioxidant ne-anti-inflammatory.
Ngamafuphi,i-glabridinikakhulukazi ivimbela i-melanogenesis ngezindlela ezintathu: ivimbela umsebenzi we-Tyrosinase, ivimbele ukukhiqizwa kwezinhlobo ze-oksijini esebenzayo, futhi ivimbele ukuvuvukala.
Ukuhlola kubonise ukuthi iyisithako esisheshayo, esisebenzayo, nesiluhlaza esimhlophe esisusa amabala. Kukhona idatha yokuhlola ebonisa ukuthi umphumela wokuba mhlophe we-Glabridin uphindwe izikhathi ezingu-232 ku-vitamin C ovamile, ophindwe izikhathi ezingu-16 kune-hydroquinone(quinone), futhi Izikhathi eziyi-1164 ze-"arbutin".
Incazelo: Ukusebenza okunamandla kanye nezinhlelo zokusebenza ezishiwo kulesi sihloko konke kuvela ezincwadini ezitholakala esidlangalaleni.
Isikhathi sokuthumela: Jun-28-2023