Kungani i-albumin-bound bound paclitaxel ingadingi ukuthi yenziwe kusengaphambili?

Njengamanje, kunezinhlobo ezintathu zamalungiselelo e-paclitaxel emakethe e-China, okuhlanganisa umjovo we-paclitaxel, i-Liposomal paclitaxel ne-Albumin-bound paclitaxel.Kokubili umjovo we-paclitaxel kanye ne-Liposomal paclitaxel yomjovo udinga ukwelashwa ngemithi yokwelapha yokungezwani komzimba, kodwa kungani i-Albumin- i-paclitaxel eboshwe ayidingi ukwelashwa?Ake sibheke okulandelayo.

Kungani i-Albumin-bound paclitaxel ingadingeki ukuthi yenziwe kusengaphambili?Manje ake siqonde indlela yokungezwani komzimba yamalungiselelo amathathu e-paclitaxel.

1.Paclitaxel umjovo

Ukwandisa ukuncibilika kwamanzi kwe-paclitaxel, isincibilikisi somjovo we-paclitaxel sakhiwe ngamafutha e-polyoxyethylene castor kanye ne-ethanol.I-Polyoxyethylene castor oil, njenge-allergen, inama-non-ionic block copolymers esakhiweni sawo samangqamuzana, angashukumisa umzimba ukuba ukhulule i-histamine. futhi kubangele ukungezwani komzimba.Ngaphambi kokusetshenziswa emtholampilo, ama-glucocorticoid nama-antihistamine kufanele asetshenziselwe ukwelapha kusengaphambili.

2.I-Liposomal paclitaxel

I-Liposomal paclitaxel ikakhulukazi i-phospholipid bimolecular liposomes enobubanzi obungu-400 nm obunjwe i-lecithin ne-cholesterol ngesilinganiso esithile.Ayiqukethe i-polyoxyethylene castor oil kanye ne-ethanol ephelele engabangela ukungezwani komzimba.

Kodwa-ke, olunye ucwaningo luye lwabonisa ukuthi i-paclitaxel ngokwayo ingabangela ukuzwela okukhulu, okuhlobene nokusebenza kwezinqubo zokuzivikela komzimba ezixhunywe ama-basophils, i-IgE ne-IgG. Kodwa uma kuqhathaniswa nomjovo we-paclitaxel, izinga layo lokungezwani komzimba liphansi. zidinga ukwelashwa kwangaphambili kwe-allergic ngaphambi kokusetshenziswa.

3.I-paclitaxel eboshwe nge-albhamu

I-albumin-bound paclitaxel, ene-albumin yomuntu njengomthwali, inezinzuzo zokubola kalula ku-vivo, ukunqwabelana kwezidakamizwa eziningi kumathumba, ukukhomba okuqinile kanye nempumelelo ephezulu ye-chemotherapy.

Ezifundweni zeSigaba I, II noma III nge-albumin-bound paclitaxel, nakuba kungazange kwenziwe ukwelashwa kusengaphambili, akukho ukusabela okukhulu kwe-hypersensitivity okutholakele. .Ngakho-ke, ukwelapha ngaphambi kokuphathwa kwe-albumin bound paclitaxel akunconywa okwamanje.

Qaphela: Ukusebenza okunamandla nezinhlelo zokusebenza ezethulwe kulesi sihloko konke kuvela ezincwadini ezishicilelwe.

I-Yunnan Hande Biotechnology Co., Ltd ibisebenza ngokukhethekile ekukhiqizenipaclitaxel APIiminyaka engaphezu kwengu-20, futhi ingomunye wabakhiqizi abazimele bezwe be-paclitaxel API, umuthi olwa nomdlavuza osuselwe esitshalweni, ogunyazwe yi-US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan kanye nezinye izinhlaka ezilawula izwe. .I-Hande ayikwazi ukunikeza izinga eliphezulu kuphelapaclitaxel izinto zokusetshenziswa,kodwa futhi nezinsizakalo zokuthuthukisa ezobuchwepheshe ezihlobene ne-paclitaxel formulation.Ngolwazi olubanzi, sicela ukhululeke ukusithinta ku-18187887160.