I-Artemisia annua ikhipha i-Artemisinin 98% yezinto zokusetshenziswa zezitshalo ezilwa nomalaleveva

Ulwazi Lomkhiqizo

Ukukhishwa kwe-Artemisia annua utshani obomile obuphelele bamakhambi onyaka i-Artemisia annua kanye ne-Artemisia annua;Ngokuyinhloko iqukethe ama-flavonoid, ama-coumarins, ama-terpenes, i-phenylpropionic acid, amafutha ashisayo namanye ama-artemisinin;Inemiphumela ye-pharmacological efana ne-antimalarial, antibacterial, antiviral, anti-inflammatory, antipyretic and analgesic, anti schistosomiasis nezinye izimuncagazi, ukungatheleleki, ukuvinjelwa kwesimila kanye nesistimu yenhliziyo;Ngokomtholampilo, isetshenziswa kakhulu ekwelapheni umalaleveva, i-yin deficiency fever, i-bone steaming fever, ukushisa okubi, i-bronchitis engapheli, i-discoid lupus erythematosus, i-oral lichen planus, i-dermatomycosis, i-neurodermatitis, i-skin pruritus, isifo sohudo sekwindla yezingane, i-epistaxis nezinye izimpawu. .
1. Izingxenye eziyinhloko
I-Artemisia annua extract ikakhulukazi ihlanganisa ama-flavonoid, ama-coumarins, ama-terpenes, i-phenylpropionic acid, uwoyela oshisayo nokunye.
2. Umsebenzi
1. Umphumela wokulwa nomalaleveva
Ukuhlola kufakazele ukuthi ingxenye engathathi hlangothi ekhishwe i-ether ye-Artemisia annua kanye nokukhishwa kwayo kotshwala obuncibilikisiwe kunemiphumela ebalulekile yokulwa nomalaleveva kumalaleveva wegundane, umalaleveva wezinkawu kanye nomalaleveva wabantu.Ukuhlolwa kwe-vivo kubonise ukuthi i-artemisinin yayinomphumela wokubulala esigabeni se-intracellular se-Plasmodium falciparum, kodwa ayizange ibe nomthelela esigabeni esingaphandle kwamaseli kanye ne-prophase ye-Plasmodium falciparum.Ingavimbela ngokushesha ukuvuthwa kwePlasmodium.Ukuhlolwa kwe-in vitro kubonise ukuthi i-artemisinin ingavimbela ngokuphawulekayo ukukhula kwama-clone e-Plasmodium falciparum futhi ibe nomthelela wokubulala oqondile.
2. Imiphumela elwa namagciwane kanye ne-antiviral
I-Artemisia annua decoction inomphumela onamandla ovimbelayo ku-Staphylococcus epidermidis, catarrhalis, anthrax kanye ne-diphtheria.Ibuye ibe nomphumela othile wokuvimbela i-Staphylococcus aureus, i-Pseudomonas aeruginosa, i-dysentery, isifo sofuba namanye ama-bacilli.Uwoyela we-Artemisia annua oguquguqukayo unomphumela ovimbelayo kuwo wonke ama-dermatophytes ekugxilweni kuka-0% no-25%, kanye nomphumela we-bactericidal kuwo wonke ama-dermatophytes ekugxilweni kuka-1%.I-Artemisinin inomphumela we-anti-influenza virus.I-sodium artesunate inemiphumela ethile yokulwa namagciwane ku-Staphylococcus aureus, Shigella flexneri, Escherichia coli, Catacoccus, paratyphoid A kanye no-B.
3. Anti-inflammatory, antipyretic kanye ne-analgesic imiphumela
I-Scopolamine equkethwe ku-Artemisia annua extract inomphumela wokulwa nokuvuvukala.Kubikwe ukuthi ingxenye encibilikayo emanzini ye-artemisinin ekhishwe ku-Artemisia annua inomphumela we-antipyretic esivivinyweni somtholampilo.Kuphinde kwabikwa ukuthi i-artemisinin ayinawo umphumela we-antipyretic.Umjovo we-Artemisia annua olungiselwe ukucwiliswa emanzini unomphumela osobala we-antipyretic konogwaja obangelwa umgomo wokugomela kathathu we-Baibai kanye ne-tetanus.
4. Anti schistosomiasis nezinye izimuncagazi
I-Artemisinin, i-artemisinin kanye nokuphuma kwayo kunemiphumela yokulwa ne-schistosomiasis.Ukuhlolwa kwamagundane kubonise ukuthi i-artemisinin inomphumela osobala wokubulala ku-Schistosoma japonicum yabantu abadala.Nakuba isikhathi sokuphromotha "ukufuduka kwesibindi" sasihamba kancane, umphumela wokubulala wawushesha futhi usobala kakhulu kwabesifazane.I-Artesunate ne-artemether zazisebenza ngempumelelo ekwelapheni amagundane kanye onogwaja abangenwe yi-Schistosoma japonicum.Kodwa-ke, i-artemether ingabangela umonakalo osobala esibindini esiphethe umthamo wokwelapha.I-Artemisinin kanye nokuphuma kwayo kunemiphumela emihle yokubulala izinambuzane kanye ne-insecticide ku-Clonorchis sinensis.
5. Umphumela kumasosha omzimba
I-Artemether inganciphisa okuqukethwe kwe-serum IgG futhi ikhulise isisindo sobende kumagundane avamile.Yehlisa okuqukethwe kwe-serum IgG kumagundane enkukhu erythrocyte azwelayo.I-Artemisinin ne-artemether ingakhuthaza ukwanda kwamaseli e-spleen TS futhi ivimbele i-IgG.I-Intramuscular artemether iphinde yehlisa i-T, B, Tu kanye ne-tr lymphocyte egazini le-peripheral lezinja ze-begle.
6. Imiphumela ohlelweni lwenhliziyo nemithambo yegazi
Ukulawulwa komlomo kwengxenye engathathi hlangothi ekhishwe ku-Artemisia annua ether akuzange kube nomthelela omkhulu ekushayeni kwenhliziyo yamakati nezinja, umfutho wegazi kanye ne-ECG.Ukuhlolwa kwe-in vitro free heart perfusion kwabonisa ukuthi i-artemisinin inganciphisa izinga lokushaya kwenhliziyo, ivimbele ukufinyela kwe-myocardial futhi yehlise ukugeleza kwegazi le-coronary.I-Artemisinin inganciphisa izinga lokushaya kwenhliziyo ngokujova ngomlomo noma ngomjovo.Ukuze uthole i-arrhythmia ebangelwa i-aconitine konogwaja, i-artemisinin 20 mg / kg inomphumela othile we-antiarrhythmic.
7. Umphumela we-Antitumor
Ukuhlola kubonisa ukuthi i-artemisinin ivimbela ukukhula, ukwanda kanye nokumetastasis kwamangqamuzana omdlavuza ngezindlela ezihlukahlukene, futhi ekugcineni ibangele i-apoptosis yawo.Kufakazelwa ukuthi i-artemisinin inomphumela ovimbelayo kumaseli ahlukahlukene wesimila, futhi ubuthi bayo kumaseli ezicubu ezijwayelekile buphansi kakhulu.
8. Umphumela enhliziyweni
I-Artemisinin ekukhishweni kwe-Artemisia annua inganciphisa izinga lokushaya kwenhliziyo, ivimbele ukufinyela kwe-myocardial futhi yehlise ukugeleza kwenhliziyo.
3. Inkambu yohlelo lokusebenza
1. Imboni yezemithi
2. Imboni yezimonyo

Amapharamitha womkhiqizo

1.Yonke imikhiqizo ethengiswa yinkampani iyimpahla esetshenziswayo engaqediwe.Imikhiqizo iqondiswe kakhulu kubakhiqizi abaneziqu zokukhiqiza, futhi izinto ezingavuthiwe aziyona imikhiqizo yokugcina.
2.Impumelelo engaba khona kanye nezicelo ezihilelekile esingenisweni konke kuvela ezincwadini ezishicilelwe.Abantu ngabanye abancomi ukusetshenziswa okuqondile, futhi ukuthenga ngakunye kwenqatshwa.
3.Izithombe kanye nemininingwane yomkhiqizo kule webhusayithi ingeyereferensi kuphela, futhi umkhiqizo wangempela yiwo oyosebenza.