I-Artemisinin 99% i-Artemisia annua ikhipha izinto zokusetshenziswa zemithi

Ulwazi Lomkhiqizo

I-Artemisinin umuthi onomphumela omuhle kakhulu ekwelapheni umalaleveva.Kuyi-sesquiterpene lactone eneqembu le-peroxide ekhishwe ku-Artemisia annua.Inezici zokusebenza kahle okuphezulu, umphumela osheshayo, ukususa ukushisa kanye nokukhulula ukushisa kwehlobo, ukunciphisa ukushisa okuntulekayo, ukubulala i-protozoa kanye nobuthi obuphansi.Njengamanje, ukusebenza kahle kwe-artemisinin based therapy (ACT) yokwelapha umalaleveva sekufinyelele ngaphezu kwama-90% emhlabeni jikelele.Isetshenziswe kabanzi ekwelapheni umalaleveva emhlabeni wonke.
1. Umsebenzi
1. Ukunqanda umalaleveva
Umalaleveva (owaziwa kakhulu ngokuthi yi-pendulum cold and fever fever) yisifo esithathelwanayo esithwalwa yizinambuzane.Kuyisifo esithathelwanayo esibangelwa ukulunywa emzimbeni womuntu otheleleke ngePlasmodium.Ingabonakala i-hepatosplenomegaly kanye ne-anemia ngemva kokuhlaselwa okuphindaphindiwe isikhathi eside.I-Artemisinin ibe negalelo ekwelapheni umalaleveva ngezinga elithile.Ibhondi ye-peroxide esakhiweni se-artemisinin i-oxidizing futhi iyiqembu elibalulekile lokumelana nomalaleveva.Indlela yokusebenza ukuthi iqembu lamahhala elikhiqizwa i-artemisinin ku-vivo libophezela kuphrotheni ye-Plasmodium falciparum futhi liguqule ukwakheka kweseli ye-Plasmodium falciparum.Ngemva kokuba ama-radicals amahhala ehlangene ne-Plasmodium protein, ulwelwesi lwe-bilayer lwe-mitochondria luzovuvukala futhi luqhekeke, futhi ekugcineni liwe, okuholela ekubhidlikeni kwesakhiwo samangqamuzana nokusebenza kwePlasmodium, kanti i-chromatin kunucleus nayo izothinteka kwabanye. ububanzi.
2. I-Antitumor
Isimila esiyingozi singumbulali wokuqala obeka impilo yomuntu engcupheni.Uma ingelashwa ngesikhathi, izofaka ukuphepha kwempilo engozini.Ukuhlolwa kwe-in vitro kubonise ukuthi umthamo othile we-artemisinin ungabangela i-apoptosis yezinhlobo eziningi zamaseli omdlavuza, njengamaseli e-hepatoma, amaseli omdlavuza webele, amaseli omdlavuza womlomo wesibeletho nokunye, futhi avimbele ngokuphawulekayo ukukhula kwamangqamuzana omdlavuza.Kutholakala ukuthi i-artemisinin ingalawula ukuvezwa kwe-cyclin kumaseli wesimila, ithuthukise umphumela wama-CKI futhi iholele ekuboshweni komjikelezo weseli yesimila;Noma kuholele ku-apoptosis futhi kuvimbele i-angiogenesis yesimila ukumelana nokuvela nokuthuthukiswa kwesimila.I-Artemisinin isetshenziselwa ukwelapha i-leukemia ngokusebenza kulwelwesi lwamaseli we-leukemia, ikhulise ukungena kwe-membrane futhi iguqule ingcindezi ye-osmotic, okuholela ekwandeni kokuhlushwa kwe-calcium emangqamuzaneni, ukuze kusebenze i-calpain, yenze ulwelwesi lweseli luvuvuke. futhi i-crack, isheshise ukukhululwa kwezinto ze-apoptotic futhi ikhulise isivinini se-apoptosis.
3. Ukwelashwa kwe-hypertension yamaphaphu
I-pulmonary hypertension (PAH) yisimo se-pathophysiological esibonakala ngokulungiswa kabusha komthambo wamaphaphu kanye nokukhuphuka komfutho we-pulmonary artery ufike kumkhawulo othile.Kungaba i-complication noma i-syndrome.I-Artemisinin isetshenziselwa ukwelapha umfutho wegazi ophakeme wamaphaphu: inganciphisa umfutho we-pulmonary artery futhi ithuthukise izimpawu ezigulini ezine-PAH ngokuphumuza imithambo yegazi.Zaiman et al.Kutholwe ukuthi i-artemisinin inomphumela wokulwa nokuvuvukala.I-Artemisinin kanye nezinto zayo eziyinhloko zingavimbela izici ezihlukahlukene zokuvuvukala, futhi zingavimbela ukukhiqizwa kwe-nitric oxide ngabaxhumanisi abavuthayo;I-Artemisinin inomphumela we-immunomodulatory;U-Feng Yibai nabanye bathola ukuthi i-artemisinin ingavimbela ukwanda kwamangqamuzana e-vascular endothelial kanye namaseli emisipha abushelelezi emithambo, bese idlala indima ebalulekile ekwelapheni kwe-PAH;I-Artemisinin ingavimbela umsebenzi we-metalloproteinase ye-matrix, ngaleyo ndlela ivimbele ukulungiswa kabusha kwe-vascular pulmonary;I-Artemisinin ingavimbela ukuvezwa kwama-cytokines ahlobene ne-PAH futhi ithuthukise nakakhulu umphumela wokuvuselela imithambo ye-artemisinin.
4. Ukulawulwa kwamasosha omzimba
Kutholakala ukuthi umthamo we-artemisinin kanye nokuphuma kwayo kungavimbela kangcono i-T lymphocyte mitogen futhi kubangele ukwanda kwama-lymphocyte we-spleen yegundane ngaphandle kwe-cytotoxicity.Lokhu okutholakele kunenani elihle lokubhekisela ekwelapheni izifo ze-T lymphocyte mediated autoimmune.I-Artemisia annua glass vinegar ingathuthukisa ukuzivikela okungaqondile futhi ithuthukise umsebenzi ophelele weserum yegundane.I-Dihydroartemisinin ingavimbela ngokuqondile ukwanda kwama-lymphocyte e-B, inciphise ukukhiqizwa kwama-autoantibodies ngama-lymphocyte e-B, inciphise ukuphendula kwamasosha omzimba, ivimbele ukungatheleleki kwe-humoral futhi inciphise ukwakheka kwama-immune complexes.
5. I-Antifungal
Umthelela we-artemisinin we-antifungal wenza futhi i-artemisinin ibonise umsebenzi othile wokulwa namagciwane.Ucwaningo luqinisekisile ukuthi impushana esele kanye ne-decoction yamanzi ye-artemisinin yayinemiphumela eqinile ye-antibacterial ku-anthrax, i-Staphylococcus epidermidis, i-catarrhalis ne-diphtheria, futhi yaba nemiphumela ethile yokulwa namagciwane ku-tuberculosis, i-Pseudomonas aeruginosa, i-Staphylococcus aureus ne-dysentery bacilli.
2. Inkambu yohlelo lokusebenza
I-Artemisia annua isetshenziswa njengesidakamizwa esilwa nomalaleveva.Ukusetshenziswa kwayo emtholampilo kufakazele ukuthi i-artemisinin kanye nokuphuma kwayo kunemiphumela ekhethekile ku-Plasmodium falciparum kanye ne-Plasmodium falciparum, ikakhulukazi i-Artemisia annua a, enomthelela onamandla kuneminye imithi ye-artemisinin ekubulaleni ama-clone e-intracellular e-Plasmodium falciparum.

Amapharamitha womkhiqizo

IPHROFAYELA YENKAMPANI
Igama Lomkhiqizo	Ai-rtemisinin
CAS	63968-64-9
I-Chemical Formula	I-C15H22O5
Birandi	Hfuthi
Mumenzi	YUnnan Hande Bio-Tech Co., Ltd.
Cukuphuma	Kunming,Chawu
Imisiwe	1993
BULWAZI LWE-ASIC
Omqondofana	3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h) -one,octahydro-3,6,9-tri;artemisiaannual.,extract;huanghuahaosu;i-octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j) -1,2-benzodioxepin-10(;qinghausau;qinghausu; I-QHS; I-ARTEMISIN99%
Isakhiwo
Isisindo	282.34
HIkhodi ye-S	N/A
IkhwalithiSukucaciswa	Ukucaciswa Kwenkampani
Cizitifiketi	N/A
Isivivinyo	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Ukubukeka	Ikristalu ye-acicular engenambala
Indlela Yokukhipha	I-Artemisia ngonyaka
Amandla Wonyaka	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Iphakheji	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Indlela Yokuhlola	N/A
Logistics	Okuningiezokuthuthas
PaymentTerms	T/T, D/P, D/A
Olapho	Yamukela ukuhlolwa kwamakhasimende ngaso sonke isikhathi;Siza amaklayenti ngokubhaliswa kokulawula.

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