Iqabunga likamalibhele DNJ iqabunga likamalibhele likhipha impahla yomkhiqizo wezempilo

Ulwazi Lomkhiqizo

Iqabunga likamalibhele i-DNJ i-alkaloid yemvelo, igama layo lesiShayina lingu-1-deoxynojirimycin.Kuyi-enzyme enamandla eyenza i-glucose metabolizing (isb. i-α-Glycosidase) inhibitor ingabambezela ngokuphawulekayo inqubo yokuwohloka kwe-polysaccharide, yehlise inani eliphakeme kakhulu likashukela wegazi wangemva kokudla kanye nokuzinzisa ushukela wegazi ozila ukudla;Iyingxenye "ye-inhibitory factor" phakathi kwezici ezine ezilawula ushukela we-alfa.
1, Umphumela weqabunga likamalibhele DNJ
1. Indlela emithathu yokwehlisa ushukela wegazi
Njengesivimbeli esinamandla se-glucose metabolizing enzymes (isb. i-α-Glucosidase, i-hexokinase, i-glucuronidase ne-glycogen phosphatase, njll.), i-DNJ ingalibazisa kakhulu inqubo yokuwohloka kwe-polysaccharide, yehlise inani eliphakeme le-postprandial glucose egazini futhi izinze ukuzila ukudla kweglucose yegazi.Ngaphezu kwalokho, i-DNJ inomphumela wokuzwela kwe-insulin ukuthuthukisa ukumelana ne-insulin.
2. Yehlisa ushukela wegazi wangemva kokudla.
I-α- I-Glucosidase isatshalaliswa kakhulu emathunjini amancane omuntu futhi idlala indima ebalulekile ekuboleni kwama-carbohydrate.Banesibopho sokubola kwama-oligosaccharides afana nama-oligosaccharides ekudleni abe yi-monosaccharides, njenge-glucose.Lawa ma-glucose angena emzimbeni ngodonga lwamathumbu, okubangela ukukhuphuka okubukhali kokugcwala kweglucose egazini.I-DNJ ingokwemvelo futhi inamandla i-α-Glucosidase inhibitors ebopha ngokuncintisana emathunjini amancane α- Ukuhlobana kwe-glucosidase kuphakeme kunokwe-oligosaccharides njenge-sucrose ne-maltose , ukuze kuvinjwe ukubola kwe-fructose ku-glucose, futhi inani elikhulu likashukela ngeke limuncwe futhi lithunyelwe emathunjini amakhulu.Ngenxa yomphumela we-DNJ, i-glucose encane ingena egazini, ngakho-ke i-glucose yegazi kufanele igcinwe isezingeni elinempilo.
3. Ukuzila ukudla okuzinzile kweglucose yegazi.
I-DNJ inomsebenzi ovimbelayo we-glycogen phosphorylase, enganciphisa ukuwohloka kwe-glycogen yesibindi ibe yi-glucose, ukuze kuzinzise ukuzila ukudla kweglucose yegazi.Iglucose "eqile" emzimbeni womuntu igcinwa esibindini isesimweni se-glycogen.I-Glycogen ingahlukaniswa ibe ushukela ngaphansi kwesenzo se-glycogen phosphorylase futhi ikhishwe egazini ukuze ihlangabezane nezidingo zemisipha nezinye izitho zomzimba.I-Glycogen ingenye yemithombo yamandla eyinhloko yokusebenza komzimba.Ngokushintshana phakathi kwe-glycogen ne-glucose, ushukela osegazini labantu abajwayelekile usesilinganisweni esiguqukayo.Ezigulini ezinesifo sikashukela, ngenxa yokungasebenzi kahle kwe-glucose metabolism, i-glycogen eningi izoqhekeka ibe i-glucose, okuholela ekwenyukeni okungavamile koshukela wegazi ozila ukudla.I-DNJ ingavimbela ukusebenza kwe-glycogen phosphorylase futhi ivimbele ukwanda kweglucose egazini okubangelwa ukubola kwe-glycogen eyeqile ibe yi-glucose, ukuze kuzinziswe ukuzila ukudla kweglucose yegazi.
4. Thuthukisa ukumelana ne-insulin.
I-DNJ ingathuthukisa izimpawu zokungazweli kwe-insulin ngokulungisa i-lipid metabolism, ibambezele ukukhiqizwa kwe-glucose kanye nokuzwela kwe-insulin.Ukumelana ne-insulin kusho izizathu ezihlukahlukene (ikakhulukazi ezihlanganisa izici zofuzo kanye nokukhuluphala), okunciphisa ukusebenza kahle kwe-insulin ekhuthaza ukumuncwa kwe-glucose nokusetshenziswa kwayo, futhi umzimba unxephezela ukukhiqiza i-insulin eningi kakhulu.Ukumelana ne-insulin kukhiqiza i-hyperinsulinemia ukuze kugcinwe ukuzinza kweglucose egazini.Uma umzimba womuntu usesimweni sokumelana ne-insulin isikhathi eside, kuzokwandisa kakhulu umthwalo wamanyikwe.Kungase kubangele ukuthi ama-pancreas akhiqize ukwehluleka kokusebenza kwe-insulin bese abe nesifo sikashukela.I-DNJ ingathuthukisa izimpawu zokungazweli ku-insulin ngokugcina ushukela wegazi unempilo, ilungise i-lipid metabolism nokwandisa ukuzwela kwe-insulin.
2, Izinkambu zokufaka isicelo zeqabunga likamalibhele DNJ
Iqabunga likamalibhele elikhipha iqabunga likamalibhele i-DNJ ibhalwe njengomphumela osizayo we-hypoglycemic futhi isetshenziswa kabanzi ekudleni kwezempilo.

Amapharamitha womkhiqizo

IPHROFAYELA YENKAMPANI
Igama Lomkhiqizo	Iqabunga likamalibhele DNJ
CAS	19130-96-2
I-Chemical Formula	I-C6H13NO4
Birandi	Hfuthi
Mumenzi	YUnnan Hande Bio-Tech Co., Ltd.
Cukuphuma	Kunming,Chawu
Imisiwe	1993
BULWAZI LWE-ASIC
Omqondofana	(2r,3r,4r,5s)-2-hydroxymethyl-3,4,5-trihydroxypiperidine;5-piperidinetriol,2-(hydroxymethyl)-,(2r-(2alpha,3beta,4alpha,5beta))-4;bay-h5595;moranolin;moranoline; (+)-1-DEOXYNOJIRIMYCIN;1-DEOXYNOJIRIMYCIN;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL
Isakhiwo
Isisindo	N/A
HIkhodi ye-S	N/A
IkhwalithiSukucaciswa	Ukucaciswa Kwenkampani
Cizitifiketi	N/A
Isivivinyo	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Ukubukeka	Impushana emhlophe
Indlela Yokukhipha	Ikhishwe emaqabunga kamalibhele namagxolo ezimpande
Amandla Wonyaka	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Iphakheji	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Indlela Yokuhlola	I-HPLC
Logistics	Okuningiezokuthuthas
PaymentTerms	T/T, D/P, D/A
Olapho	Yamukela ukuhlolwa kwamakhasimende ngaso sonke isikhathi;Siza amaklayenti ngokubhaliswa kokulawula.

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