Umehluko kanye nezinzuzo phakathi kwe-paclitaxel yemvelo kanye ne-semi-synthetic

I-Paclitaxel iyisidakamizwa esibalulekile sokulwa nomdlavuza, futhi ukwakheka kwayo okuyingqayizivele kanye nomsebenzi webhayoloji kudonse ukunaka okukhulu kososayensi.Ngokomthombo wayo nendlela yokuwulungiselela, i-paclitaxel ingahlukaniswa ibe yi-paclitaxel yemvelo kanye ne-semi-synthetic paclitaxel.Le ndatshana izoxoxa ngomehluko kanye nezinzuzo kokubili.

Umthombo nendlela yokulungiselela

I-paclitaxel yemvelo:I-paclitaxel yemvelo ikhishwa kakhulu esihlahleni se-Pacific yew(Taxus brevifolia).Lesi sihlahla sicebile nge-paclitaxel,kodwa ngobuningi obulinganiselwe,okwenza ukutholakala kwe-paclitaxel yemvelo kube yindlala uma kuqhathaniswa.

I-semi-synthetic paclitaxel:I-semi-synthetic paclitaxel ihlanganiswa yi-chemical synthesis evela ku-taxane ekhishwe egxolweni le-taxus chinensis.Le ndlela ingasetshenziswa ukukhiqiza i-paclitaxel ngezinga elikhulu ukuze kuhlangatshezwane nezidingo zomtholampilo.

Isakhiwo samakhemikhali

Nakuba i-paclitaxel yemvelo kanye ne-semi-synthetic paclitaxel zihluka kancane ngesakhiwo samakhemikhali, ukwakheka kwazo okuyisisekelo kuyefana, futhi zombili zingama-alkaloid e-diterpenoid.Lesi sakhiwo esiyingqayizivele sibanika umsebenzi ofanayo wezinto eziphilayo.

Umsebenzi webhayoloji nokusebenza ngempumelelo

I-Natural paclitaxel:Emisebenzini yomtholampilo, i-paclitaxel yemvelo ikhonjiswe ukuthi inomthelela omkhulu wokwelapha ezinhlobonhlobo zomdlavuza, okuhlanganisa nomdlavuza webele, umdlavuza wesibeletho, umdlavuza wekhanda nowentamo, kanye nomdlavuza wamaphaphu. ye-tubulin futhi ibhubhise inethiwekhi ye-cell microtubule, ngaleyo ndlela ivimbele ukwanda kwamaseli futhi ibangele i-apoptosis yamaseli omdlavuza.

I-Semi-synthetic paclitaxel:I-Semi-synthetic paclitaxel iyafana ngokusebenza ngempumelelo ku-paclitaxel yemvelo futhi futhi inomsebenzi obalulekile wokulwa nomdlavuza.Ukukhiqizwa ngobuningi be-semi-synthetic paclitaxel kungakhuphula ukuhlinzekwa komtholampilo futhi kunikeze izinketho zokwelashwa ezengeziwe ezigulini ezinomdlavuza.

Imiphumela emibi enobuthi

I-paclitaxel yemvelo:Ubuthi be-paclitaxel yemvelo buphansi, kodwa busengadala ukusabela okungekuhle, njengokungezwani komzimba, ukucindezelwa komnkantsha kanye nobuthi benhliziyo.

I-semi-synthetic paclitaxel:Imiphumela emibi ye-semi-synthetic paclitaxel ifana naleyo ye-paclitaxel yemvelo.Zombili zidinga imithi enengqondo esekelwe ezimweni zomuntu ngamunye kanye nezincomo zikadokotela ukuze kuncishiswe ingozi yokusabela okubi.

Amathemba entuthuko yesikhathi esizayo

Ngokuqhubeka okuqhubekayo kwesayensi nobuchwepheshe, ucwaningo lwe-paclitaxel nalo luyajula.Esikhathini esizayo, ososayensi bazosebenzela ukuthola izindlela ezisebenza kahle kakhulu ze-paclitaxel synthesis ukuze baqhubeke nokuthuthukisa inqubo yayo yokukhiqiza nokuthuthukisa ukusebenza kahle komtholampilo.Ngasikhathi sinye, ukuthuthukiswa kobuchwepheshe obusafufusa obunjengobunjiniyela bezakhi zofuzo kanye nokwelashwa kwamaseli, amasu okwelashwa komuntu siqu e-paclitaxel azokwazi, ngaleyo ndlela kunikeze iziguli ezinomdlavuza izinketho zokwelashwa ezinembe kakhudlwana nezisebenza ngempumelelo.

Isiphetho

Kokubilii-paclitaxel yemvelofuthii-semi-synthetic paclitaxelbanomsebenzi obalulekile wokulwa nomdlavuza emisebenzini yomtholampilo.Nakuba imvelaphi yabo nezindlela zokuwulungiselela zihlukile, babelana ngokufana kwesakhiwo samakhemikhali, umsebenzi webhayoloji kanye ne-pharmacodynamics.Ukukhiqizwa okukhulu kwe-semi-synthetic paclitaxel kungakhuphula ukutholakala komtholampilo, kuyilapho i-paclitaxel yemvelo ine- Umthombo ocebile ongaba namandla.Ocwaningweni oluzayo, ososayensi bazoqhubeka nokuhlola izindlela zebhayoloji zokwenza kanye nezindawo ezisetshenziswayo ze-paclitaxel ukuletha ithemba elengeziwe lokwelapha ezigulini ezinomdlavuza.

Qaphela:Izinzuzo ezingaba khona kanye nezicelo ezivezwe kulesi sihloko zithathwe ezincwadini ezishicilelwe.