Ngaphezu kokuvinjwa okungenzeka kwe-COVID 19, yimiphi imiphumela ye-Cepharanthine?

I-Cepharanthine, umuthi wendabuko oyisimangaliso wamaShayina, iyi-alkaloid ye-isoquinoline eyenzeka ngokwemvelo ekhishwe ku-Stephania.cepharanthaI-Hayata.

Ngo-2022, waba ngummeleli wethemba futhi wayekhathazeke yiwo wonke umuntu, enethemba lokuba umbulali ophumelelayo ukuxazulula i-covid 19. Ngaphezu kokuba isitshalo esithandwayo esikhishwe kulo nyaka, i-cepharanthine iyisidakamizwa esisetshenziswa eJapane kusukela ngawo-1950 ukwelapha. izifo ezihlukahlukene eziyingozi nezingamahlalakhona, okuhlanganisa i-leukopenia, ukulunywa yinyoka, umlomo owomile nokulahlekelwa izinwele.

Ngakho i-Cepharanthine ingasetshenziswa kuphi?

● Umsebenzi we-Antitumor

I-Cepharanthine inomphumela ongase ube ne-antitumor.I-Cepharanthine iyodwa ingadlala indima ye-antitumor ngokuvimbela ukwanda kwamangqamuzana e-tumor futhi ithuthukise ukuzivikela komzimba.Okuthembisayo nakakhulu ukuthi i-Cepharanthine ehlangene nemithi ye-chemotherapeutic ingathuthukisa ukusebenza kwe-chemotherapy ngokunciphisa ukumelana nezidakamizwa amaseli.Indlela eyinhloko ingase ibe ukuthi i-stephanine ingandisa ukuqoqwa kwezidakamizwa ezilwa nomdlavuza emangqamuzaneni ngokuphazamisa umsebenzi we-plasma membrane.

● Ama-analgesics

I-Cepharanthineingasetshenziselwa i-analgesia yomuthi wendabuko waseShayina futhi ikhulule izinhlungu zeziguli.

●Thuthukisa ukwanda kwe-leukocyte

I-Cepharanthine, isidakamizwa sokwanda kwe-leukocyte, ingakhuthaza ukwanda kwezicubu zomnkantsha futhi kwandise i-leukocyte.Indlela yayo ukukhuthaza ukwanda kwezicubu zomnkantsha, okuholela ekwandeni kwe-leukocyte.Isetshenziselwa i-agranulocytosis ebangelwa i-tumor chemotherapy kanye ne-radiotherapy. kanye ne-leukopenia ebangelwa ezinye izizathu.

Ngaphezu kwalokho, i-CEP ehlanganiswe nemithi elwa nesimila iyatuswa ekwelapheni i-immunosuppression kanye ne-thrombocytopenia ebangelwa ukwelashwa nge-radiotherapy nokwelashwa ngamakhemikhali, futhi ayikho imiphumela emibi esobala. , engavimbela ukutheleleka kwe-SARS, i-HIV, i-HSV-1, i-covid-19 negciwane le-Ebola, futhi yelaphe izifo ezihlukahlukene ze-autoimmune kanye nokungezwani komzimba.

Noma ngabeI-Cepharanthineangathola izindaba ezinhle emgwaqeni wokuvimbela kanye ne-antiviral esikhathini esizayo esiseduze, yilokhu esikubheke ngabomvu okwamanje, futhi kufakazela impumelelo yemithi yendabuko yamaShayina.I-Yunnan hande ikunikeza isevisi eqotho kanye ne-Cepharanthine engcono kakhulu.