Isevisi Yokudluliswa Kwezobuchwepheshe Yezimo Ze-Paclitaxel Ezivamile

Isevisi Yokudluliswa Kwezobuchwepheshe Yezinto Ezivamile Ze-Paclitaxel Formulations Isithombe Esifakiwe

Incazelo emfushane:

I-Paclitaxel iyisidakamizwa esilwa nesimila esisetshenziswa kakhulu.Umjovo we-paclitaxel osetshenziswa njengamanje emtholampilo usebenzisa uwoyela we-polyoxyethylene castor njenge-solubilizer, kodwa izehlakalo zokusabela kabi ziphezulu ngesikhathi sokusetshenziswa emtholampilo, ngakho isiguli sidinga ukwelashwa okulwa nokungezwani komzimba ngaphambi kokuphathwa, okuletha ukuphazamiseka okuningi ezigulini nakodokotela.Ukuze kuqedwe ukusabela okungekuhle okubangelwa uwoyela we-polyoxyethyl castor,unqobe ubuthakathaka bamalungiselelo akhona,futhi andise ukuncibilika nokuzinza kwe-paclitaxel,i-Albumin-bound paclitaxel yaba khona.I-Hande Biotech inikeza Ubuchwepheshe Isevisi yokudlulisa ye-Conventional Paclitaxel Formulations.Ukuthola imininingwane eyengeziwe, sicela uthintane ku-inthanethi.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-Paclitaxel

I-metabolite yesibili engokwemvelo ehlukanisiwe futhi yahlanzwa emagxolweni, amagatsha namaqabunga e-gymnospermous taxus chinensis ingakhuthaza ukwenziwa kwe-microtubule polymerization futhi izinze ama-microtubules anziwe nge-polymerized.Amaseli avezwe ku-paclitaxel azoqongelela inani elikhulu lama-microtubules kumaseli.Ukunqwabelana kwala ma-microtubules kuphazamisa imisebenzi ehlukahlukene yamangqamuzana, ikakhulukazi ukumisa ukuhlukana kwamangqamuzana esigabeni se- mitotic, futhi kuvimbe ukuhlukana kwamaseli okuvamile.

Njengamanje, ukusetshenziswa kakhulu kwe-paclitaxel imijovo elwa nomdlavuza kanye nemishini yezokwelapha (okuhlanganisa ama-stents namabhaluni) .Ngokuthuthuka okusheshayo kwe-biotechnology kanye nobuchwepheshe bezokwelapha, ukusetshenziswa kwe-paclitaxel nakho kuhlolwa njalo, futhi izimo ezihlukene zeziguli nazo zithuthukiswa ngokuqhubekayo.Kholwa ukuthi esikhathini esizayo esiseduze, kuzophepheka futhi kube lula ekwelapheni odokotela neziguli, futhi kuzoba nezinhlobonhlobo zemithi elwa nomdlavuza equkethe i-paclitaxel enomphumela onamandla wokulwa nomdlavuza.

Inqubekelaphambili yephrojekthi

Ucwaningo lwangaphambi komtholampilo seluqediwe futhi inqubo yokulungiselela isivuthiwe.