I-Dihydroartemisinin CAS 81496-82-4 Artemisia annua extract

Ulwazi Lomkhiqizo

I-Dihydroartemisinin iphuma ku-artemisinin, enomthelela oqinile futhi osheshayo wokubulala esigabeni se-erythrocytic sezinambuzane zikamalaleveva, futhi ingalawula ngokushesha ukuhlaselwa kanye nezimpawu zomtholampilo.
1, Isitshalo somthombo
I-Dihydroartemisinin iwumphumela we-artemisinin.I-Artemisinin umuthi wokulwa nomalaleveva okhishwe ku-Artemisia annua.
2. Indima
Isenzo sekhemisi se-dihydroartemisinin siyefana nese-artemisinin.Umphumela we-artemisinin ku-ultrastructure ye-Plasmodium falciparum esigabeni se-erythrocytic ngokuyinhloko ukuguqula ukwakheka kwayo kolwelwesi.Isidakamizwa siqala ukusebenza kulwelwesi lwe-vesicle yokudla, ulwelwesi olungaphezulu kanye ne-mitochondria, kulandele ulwelwesi lwenuzi kanye ne-endoplasmic reticulum.Ngaphezu kwalokho, iphinde ithinte i-chromatin ku-nucleus.Ingase isebenze kulwelwesi lwe-vesicle yokudla, ivimbe isigaba sokuqala sokudla okunomsoco kwesinanakazana sikamalaleveva, sibangele i-parasite kamalaleveva ukuba silambe ngokushesha ama-amino acid, senze ngokushesha ama-autophagic vesicles, futhi siphume ngokuqhubekayo emzimbeni, silahlekelwe inani elikhulu lama-amino acid. cytoplasm kanye nezakhi, kodwa hhayi kulekelelwa, ngakho ifa ngokushesha.Indlela yayo yokwenza ngokuyinhloko iwukuphazamisa umsebenzi we-Plasmodium surface membrane mitochondria.Ngebhuloho layo langaphakathi le-peroxide (i-dioxygen), ilamulwa yinsimbi yamahhala ekhiqizwa ngemva kokubola kwe-hemoglobin ukuze ikhiqize ama-radicals amahhala aphilayo kanye / noma amanye ama-electrophilic intermediates, bese yakha ama-covalent adducts namaprotheni e-parasite ye-malaria, okuholela ekutheni ukufa kwe-malaria.Ukuthathwa kwe-tritium ebizwa ngokuthi i-isoleucine yi-Plasmodium falciparum in vitro ekhulisiwe kuphinde kwabonisa ukuthi indlela yayo yokuqala ingase ibe ukuvimbela ukuhlanganiswa kwephrotheni ye-Plasmodium.
3. Inkambu yohlelo lokusebenza
1. Imboni yezemithi

Amapharamitha womkhiqizo

IPHROFAYELA YENKAMPANI
Igama Lomkhiqizo	I-Dihydroartemisinin
CAS	81496-82-4
I-Chemical Formula	I-C15H24O5
Birandi	Hfuthi
Mumenzi	YUnnan Hande Bio-Tech Co., Ltd.
Cukuphuma	Kunming,Chawu
Imisiwe	1993
BULWAZI LWE-ASIC
Omqondofana	(3R,5aS,6R,8aS,9R,12S,12aR)-octahydrogen -3,6,9-trimethyl -3,12-epoxy -12H-pyrane [4,3-j]-1,2-coumaron -10 ( 3H ) utshwala;Dihydroartemisinin;Dihxdroarteannui;Dihydroartemisinin USP/EP/BP
Isakhiwo
Isisindo	284.35
HIkhodi ye-S	N/A
IkhwalithiSukucaciswa	Ukucaciswa Kwenkampani
Cizitifiketi	N/A
Isivivinyo	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Ukubukeka	Ikristalu elimhlophe
Indlela Yokukhipha	U-Artemisia annua Linn.
Amandla Wonyaka	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Iphakheji	Kwenziwe ngokwezifiso ngokwezidingo zekhasimende
Indlela Yokuhlola	I-HPLC
Logistics	Okuningiezokuthuthas
PaymentTerms	T/T, D/P, D/A
Olapho	Yamukela ukuhlolwa kwamakhasimende ngaso sonke isikhathi;Siza amaklayenti ngokubhaliswa kokulawula.

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