Ikhwalithi ephezulu ye-10-DAB Semi-synthetic Paclitaxel GMP ifektri

Ulwazi Lomkhiqizo

Igama:10-DAT Semi-synthetic Paclitaxel

Inombolo ye-CAS:33069-62-4

Ifomula yekhemikhali:I-C47H51NO14

Imininingwane:99%-102%

Umbala:impushana emhlophe noma ecishe ibe mhlophe

Umthombo:I-Taxus yunnanensis, i-Taxus chinensis

Uhlobo:Ama-API

Indlela yokutholwa nempilo yeshelufu

Indlela yokuthola:I-HPLC

Ukufaneleka:3 iminyaka

Isikhathi sokuhlolwa kabusha:Izinyanga ezingama-36

Umthamo wesandla:600-800kg / ngonyaka

Umphumela

I-10-DAB semi-synthetic paclitaxel inemisebenzi eminingi ekwelashweni kwesimila.Kuwumuthi osebenza kahle kakhulu wokulwa nesimila, ongavimbela ukuhlukana nokwanda kwamaseli wesimila, ukhuthaze i-apoptosis yawo, futhi wandise ukuzwela kwamangqamuzana e-tumor ku-radiotherapy kanye ne-chemotherapy.Ngaphezu kwalokho, lesi sidakamizwa sinokutholakala okuhle kwe-bioavailability futhi singamuncwa ngokugcwele ngamaseli e-tumor, sithuthukise umphumela wokwelapha.Ibuye ibe nesigamu sempilo ende, enganciphisa ukuphazamiseka kokuphatha njalo.Uma kuqhathaniswa neminye imikhiqizo efanayo, i-10-DAB semi-synthetic paclitaxel inemiphumela engemihle enobuthi ephansi futhi ifaneleka kakhulu ukwelashwa kwesikhathi eside.Lo muthi ungaphinda uguqule umsebenzi we-pharmacological we-paclitaxel ngokushintsha isakhiwo sawo, ngaleyo ndlela unikeze amathuba amaningi okuthuthukiswa kwezidakamizwa.

Izinkonzo Zethu

1.Imikhiqizo:Nikeza ngezingcaphuno zezitshalo zekhwalithi ephezulu, ezihlanzeke kakhulu, izinto zokusetshenziswa zemithi, nezimaphakathi zemithi.

2.Izinsizakalo zobuchwepheshe:Izingcaphuno ezenziwe ngokwezifiso ezinemininingwane ekhethekile ngokuya ngezidingo zekhasimende.